Skip to Main content Skip to Navigation
Journal articles

Interplay Between CMGC Kinases Targeting SR Proteins and Viral Replication: Splicing and Beyond

Abstract : Protein phosphorylation constitutes a major post-translational modification that critically regulates the half-life, intra-cellular distribution, and activity of proteins. Among the large number of kinases that compose the human kinome tree, those targeting RNA-binding proteins, in particular serine/arginine-rich (SR) proteins, play a major role in the regulation of gene expression by controlling constitutive and alternative splicing. In humans, these kinases belong to the CMGC [Cyclin-dependent kinases (CDKs), Mitogen-activated protein kinases (MAPKs), Glycogen synthase kinases (GSKs), and Cdc2-like kinases (CLKs)] group and several studies indicate that they also control viral replication via direct or indirect mechanisms. The aim of this review is to describe known and emerging activities of CMGC kinases that share the common property to phosphorylate SR proteins, as well as their interplay with different families of viruses, in order to advance toward a comprehensive knowledge of their pro-or anti-viral phenotype and better assess possible translational opportunities.
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-03326901
Contributor : Anna Salvetti Connect in order to contact the contributor
Submitted on : Thursday, August 26, 2021 - 3:38:36 PM
Last modification on : Tuesday, August 31, 2021 - 3:33:05 PM

File

2021 Pastor FrontMicrobiol.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Florentin Pastor, Lulzim Shkreta, Benoit Chabot, David Durantel, Anna Salvetti. Interplay Between CMGC Kinases Targeting SR Proteins and Viral Replication: Splicing and Beyond. Frontiers in Microbiology, Frontiers Media, 2021, 12, pp.658721. ⟨10.3389/fmicb.2021.658721⟩. ⟨hal-03326901⟩

Share

Metrics

Record views

28

Files downloads

28