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Formal enantioselective synthesis of nhatrangin A

Abstract : A new and straightforward synthesis of the C 1 –C 7 core fragment of nhatrangin A was achieved in 14 steps from achiral 3-hydroxybenzaldehyde, without the need of chiral reagents or enzymatic resolution to introduce the chiral centers.
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Sophie Feuillastre, Ludovic Raffier, Béatrice Pelotier, Piva Olivier. Formal enantioselective synthesis of nhatrangin A. Organic & Biomolecular Chemistry, Royal Society of Chemistry, 2020, 18 (10), pp.1949-1956. ⟨10.1039/C9OB02639H⟩. ⟨hal-03620203⟩



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