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Saliva Quantification of SARS-CoV-2 in Real-Time PCR From Asymptomatic or Mild COVID-19 Adults

Abstract : The fast spread of COVID-19 is related to the highly infectious nature of SARS-CoV-2. The disease is suggested to be transmitted through saliva droplets and nasal discharge. The saliva quantification of SARS-CoV-2 in real-time PCR from asymptomatic or mild COVID-19 adults has not been fully documented. This study analyzed the relationship between salivary viral load on demographics and clinical characteristics including symptoms, co-morbidities in 160 adults diagnosed as COVID-19 positive patients recruited between September and December 2020 in four French centers. Median initial viral load was 4.12 log 10 copies/mL (IQR 2.95-5.16; range 0-10.19 log 10 copies/mL). 68.6% of adults had no viral load detected. A median load reduction of 23% was observed between 0-2 days and 3-5 days, and of 11% between 3-5 days and 6-9 days for the delay from onset of symptoms to saliva sampling. No significant median difference between no-symptoms vs. symptoms patients was observed. Charge was consistently similar for the majority of the clinical symptoms excepted for headache with a median load value of 3.78 log 10 copies/mL [1.95-4.58] (P < 0.003). SARS-CoV-2 RNA viral load was associated with headache and gastrointestinal symptoms. The study found no statistically significant difference in viral loads between age groups, sex, or presence de co-morbidity. Our data suggest that oral cavity is an important site for SARS-CoV-2 infection and implicate saliva as a potential route of SARS-CoV-2 transmission.
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https://hal-univ-lyon1.archives-ouvertes.fr/hal-03506939
Contributor : Florence Carrouel Connect in order to contact the contributor
Submitted on : Monday, January 3, 2022 - 5:53:39 AM
Last modification on : Thursday, January 13, 2022 - 1:42:01 PM
Long-term archiving on: : Monday, April 4, 2022 - 6:22:58 PM

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Florence Carrouel, Emilie Gadea, Aurélie Esparcieux, Jérome Dimet, Marie Elodie Langlois, et al.. Saliva Quantification of SARS-CoV-2 in Real-Time PCR From Asymptomatic or Mild COVID-19 Adults. Frontiers in Microbiology, Frontiers Media, 2022, ⟨10.3389/fmicb.2021.786042⟩. ⟨hal-03506939⟩

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