Skip to Main content Skip to Navigation
Journal articles

Periodontal Conditions and Pathogens Associated with Pre-Eclampsia: A Scoping Review

Abstract : Background: Pre-eclampsia, the second most frequent direct source of maternal mortality, is a multisystem gestational disorder characterized by proteinuria and maternal hypertension after the 20th gestational week. Although the causes of pre-eclampsia are still discussed, research has suggested that the placenta has a central place in the pathogenesis of this disease. Moreover, current surveys indicated that periodontal disorders observed during the pregnancy and more particularly, periodontal pathogens could be link to the risk of pre-eclampsia. Objectives: This article aims to review recent studies focusing on periodontal conditions and pathogens associated with pre-eclampsia. Methods: The process followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines. Results: Metabolic conditions, immunological changes, fluctuating progesterone and estrogen levels of the pregnant woman induce a dysbiosis of the oral microbiota and contribute to increase inflammation of periodontal tissues. Periodontal pathogens could diffuse through the bloodstream inducing a placenta inflammatory response as well as inflammatory molecules produced in response to periodontopathogens could migrate through the bloodstream leading to a placenta inflammatory response. Also, periodontopathogens can colonize the vaginal microbiota through the gastrointestinal tract or during oro-genital contacts. Conclusion: A cumulative bi-directional relationship between periodontal conditions, pathogens and the pre-eclampsia exists.
Complete list of metadata
Contributor : Florence Carrouel Connect in order to contact the contributor
Submitted on : Monday, July 5, 2021 - 3:27:52 PM
Last modification on : Friday, September 30, 2022 - 11:52:08 AM
Long-term archiving on: : Wednesday, October 6, 2021 - 6:41:21 PM


Gare et al 2021.pdf
Publisher files allowed on an open archive




Jocelyne Gare, Kanouté Aida, Nicolas Meda, Stéphane Viennot, Denis Bourgeois, et al.. Periodontal Conditions and Pathogens Associated with Pre-Eclampsia: A Scoping Review. International Journal of Environmental Research and Public Health, MDPI, 2021, 18 (3), pp.7194. ⟨10.3390/ijerph18137194⟩. ⟨hal-03278417⟩



Record views


Files downloads