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One-Pot, Solvent-Free Access to Unsymmetrical Ureas by Palladium-Catalysed Reductive Alkylation Using Molecular Hydrogen

Abstract : Unsymmetrical N,N′-disubstituted ureas were prepared in 60–93 % isolated yield by palladium-catalysed reductive alkylation of monosubstituted ureas using aldehydes as alkylating agents and molecular hydrogen as a clean reductant. A one-pot, solvent-free sequence was also developed from the corresponding amines.
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https://hal-univ-lyon1.archives-ouvertes.fr/hal-03249259
Contributor : Marie-Gabrielle Chautard <>
Submitted on : Friday, June 4, 2021 - 9:16:30 AM
Last modification on : Saturday, June 5, 2021 - 3:26:08 AM

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Tharwat Mohy El Dine, Simon Chapron, Marie-Christine Duclos, Nicolas Duguet, Florence Popowycz, et al.. One-Pot, Solvent-Free Access to Unsymmetrical Ureas by Palladium-Catalysed Reductive Alkylation Using Molecular Hydrogen. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2013, 2013 (24), pp.5445-5454. ⟨10.1002/ejoc.201300642⟩. ⟨hal-03249259⟩

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