One-Pot, Solvent-Free Access to Unsymmetrical Ureas by Palladium-Catalysed Reductive Alkylation Using Molecular Hydrogen

Tharwat Mohy El Dine; Simon Chapron; Marie-Christine Duclos; Nicolas Duguet; Florence Popowycz; Marc Lemaire

doi:10.1002/ejoc.201300642

Journal articles

One-Pot, Solvent-Free Access to Unsymmetrical Ureas by Palladium-Catalysed Reductive Alkylation Using Molecular Hydrogen

Tharwat Mohy El Dine ¹ Simon Chapron ¹ Marie-Christine Duclos ¹ Nicolas Duguet ¹ Florence Popowycz ² Marc Lemaire ¹

1 CASYEN - Catalyse Synthèse et Environnement

ICBMS - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires

2 ICBMS - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires

Abstract : Unsymmetrical N,N′-disubstituted ureas were prepared in 60–93 % isolated yield by palladium-catalysed reductive alkylation of monosubstituted ureas using aldehydes as alkylating agents and molecular hydrogen as a clean reductant. A one-pot, solvent-free sequence was also developed from the corresponding amines.

Keywords : Reductive alkylation, Synthetic methods, Palladium, Hydrogenation, Ureas

Document type :

Journal articles

Domain :

Chemical Sciences / Organic chemistry

Chemical Sciences / Catalysis

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https://hal-univ-lyon1.archives-ouvertes.fr/hal-03249259
Contributor : Marie-Gabrielle Chautard Connect in order to contact the contributor
Submitted on : Friday, June 4, 2021 - 9:16:30 AM
Last modification on : Tuesday, December 7, 2021 - 12:30:06 PM
Long-term archiving on: : Sunday, September 5, 2021 - 6:24:15 PM

One-Pot, Solvent-Free Access to Unsymmetrical Ureas by Palladium-Catalysed Reductive Alkylation Using Molecular Hydrogen

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One-Pot, Solvent-Free Access to Unsymmetrical Ureas by Palladium-Catalysed Reductive Alkylation Using Molecular Hydrogen

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