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Journal articles
Biphasic Glycerol/2-MeTHF, Ruthenium-Catalysed Enantioselective Transfer Hydrogenation of Ketones Using Sodium Hypophosphite as Hydrogen Donor
Abstract : Sodium hypophosphite has been used as an efficient hydrogen donor in the transfer hydrogenation of aliphatic and aromatic ketones in the presence of [RuCl2(p-cymene)]2 and 2,2′-bipyridine in water. The corresponding alcohols were isolated in moderate to excellent yields (39–95 %). Good chemoselectivity was observed with ester, nitrile and halide functionalities in the ketones not being reduced. An enantioselective version of the reaction using [RuCl(p-cymene){(R,R)-TsDPEN}] as catalyst in a glycerol/2-MeTHF biphasic solvent mixture has been developed and allowed the reduction of (hetero)aromatic ketones with excellent chemo- and enantioselectivities (up to 97 % ee).
https://hal-univ-lyon1.archives-ouvertes.fr/hal-03249234
Contributor : Marie-Gabrielle Chautard <>
Submitted on : Friday, June 4, 2021 - 8:59:13 AM
Last modification on : Friday, June 25, 2021 - 7:38:02 PM
Long-term archiving on: : Sunday, September 5, 2021 - 6:23:45 PM
Contributor : Marie-Gabrielle Chautard <>
Submitted on : Friday, June 4, 2021 - 8:59:13 AM
Last modification on : Friday, June 25, 2021 - 7:38:02 PM
Long-term archiving on: : Sunday, September 5, 2021 - 6:23:45 PM
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