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Low oxygen levels can help to prevent the detrimental effect of acute warming on mitochondrial efficiency in fish

Abstract : Aerobic metabolism of aquatic ectotherms is highly sensitive to fluctuating cli- mates. Many mitochondrial traits exhibit phenotypic plasticity in response to acute variations in temperature and oxygen availability. These responses are critical for understanding the effects of environmental variations on aquatic ectotherms’ performance. Using the European seabass, Dicentrarchus labrax, we determined the effects of acute warming and deoxygenation in vitro on mitochondrial respiratory capacities and mitochondrial efficiency to produce ATP (ATP/O ratio). We show that acute warming reduced ATP/O ratio but deoxygenation marginally raised ATP/O ratio, leading to a compensatory effect of low oxygen availability on mitochondrial ATP/O ratio at high temp- erature. The acute effect of warming and deoxygenation on mitochondrial efficiency might be related to the leak of protons across the mitochondrial inner membrane, as the mitochondrial respiration required to counteract the proton leak increased with warming and decreased with deoxygenation. Our study underlines the importance of integrating the combined effects of temperature and oxygen availability on mitochondrial metabolism. Predic- tions on decline in performance of aquatic ectotherms owing to climate change may not be accurate, since these predictions typically look at respirat- ory capacity and ignore efficiency of ATP production.
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Contributor : Nathalie Lyvet Connect in order to contact the contributor
Submitted on : Friday, February 12, 2021 - 11:50:55 AM
Last modification on : Friday, September 30, 2022 - 11:12:08 AM


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Elisa Thoral, Damien Roussel, Christos Chinopoulos, Loïc Teulier, Karine Salin. Low oxygen levels can help to prevent the detrimental effect of acute warming on mitochondrial efficiency in fish. Biology Letters, 2021, 17 (2), pp.20200759. ⟨10.1098/rsbl.2020.0759⟩. ⟨hal-03139752⟩



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