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Capturing a Single Cell

Catherine Rey 1, 2 Anne Wierinckx 3, 4 Séverine Croze 5 Catherine Legras-Lachuer 1, 6 Joel Lachuer 1, 4
1 Santé Lyon Est - Louis Léopold Ollier
2 IFNL - Institut Fédératif des Neurosciences de Lyon
3 equipe 2
ProfileXpert, UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon, labex DEVweCAN
4 Inserm U842 Lyon - Laboratoire de Neuro-oncologie et Neuro-inflammation, faculté de médecine Laennec
5 ProfileXpert
6 LEM - Laboratoire d'Ecologie Microbienne - UMR 5557
Abstract : A major problem encountered in genomic and proteomic studies arises from the heterogeneous nature of different tissue. Analysis of a pure cell population is essential for correlating relevant molecular signatures in diseased and disease-free cells. During the last 30 years this challenge has led to the development of different technologies able to isolate cells of interest. Laser capture microdissection (LCM) is the last available technology using the precision of a laser beam to isolate single cells from complex tissue. In this chapter we will review the different technologies available and some applications.
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https://hal-univ-lyon1.archives-ouvertes.fr/hal-02569424
Contributor : Marie-Gabrielle Chautard <>
Submitted on : Monday, May 11, 2020 - 12:27:45 PM
Last modification on : Monday, June 14, 2021 - 1:58:07 PM

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Catherine Rey, Anne Wierinckx, Séverine Croze, Catherine Legras-Lachuer, Joel Lachuer. Capturing a Single Cell. Unravelling Single Cell Genomics: Micro and Nanotools, RSC Publishing, pp.61-72, 2011, RSC Nanoscience and Nanotechnology, 978-1-84755-911-1. ⟨10.1039/9781849732284-00061⟩. ⟨hal-02569424⟩

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