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Screening of new antifungal compounds in a collection of chemical products

Abstract : The antifungal activity of eighteen synthetic compounds belonging to a collection of chemical products has been tested against six fungal species [Candida albicans ATCC 10231, Candida tropicalis R2 CIP 1275.81 (an amphotericin B-nystatin resistant strain), Aspergillus fumigatus CIP 1082.74, Aspergillus niger ATCC 16404, Fusarium oxysporum CIP 625.72 and Trichophyton rubrum CIP 2043.92] using the agar disk method and two test media (casitone medium and YMA medium). Ten chemical products (55% of the synthetic compounds tested) were shown to have an antifungal activity. Among them, one compound called MI showed a strong antifungal activity against all fungi tested. The antifungal activity of M1 was further characterized by determining the minimun inhibitory concentration (MIC) against the six fungal species selected using broth microdilution method and also two test media described above. The susceptibility of C. tropicalis R2 CIP 1275.81 and F. oxysporum CIP 625.72 was better for the M1 product than amphotericin B on both test media. Furthermore, M1 was more active than amphotericin B in inhibiting growth on YMA medium for C. albicans ATCC 10231 and A. fumigatus CIP 1082.74, but for A. niger ATCC 16404, best inhibition was observed on casitone medium. Moreover, according to literature the MIC of M1 was remarkable in comparison to the antifungal agents currently available for clinical use other than amphotericin B. These promising in vitro data open the way to further investigations to study toxicity and in vivo antifungal activity.
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Submitted on : Monday, April 27, 2020 - 9:18:20 AM
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S. Lemriss, B. Marquet, H. Ginestet, L. Lefeuvre, A. Fassouane, et al.. Screening of new antifungal compounds in a collection of chemical products. Journal de Mycologie Médicale, Elsevier Masson, 2003, 13 (4), pp.189-192. ⟨hal-02554983⟩

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