COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression

Florence Carrouel (1) , Maria Conte (2) , Julian Fisher , Lucio Souza Gonçalves , Claude Dussart (3) , Juan Llodra (4) , Denis Bourgeois (1)

1 P2S - Parcours santé systémique
2 CIG - Centro Interdipartimentale Galvani
3 Central Pharmacy [Lyon]
4 UGR - Universidad de Granada = University of Granada

Considered to be a major portal of entry for infectious agents, the oral cavity is directly associated with the evolutionary process of SARS-CoV-2 in its inhalation of ambient particles in the air and in expectorations. Some new generations of mouth rinses currently on the market have ingredients that could contribute to lower the SARS-CoV-2 viral load, and thus facilitate the fight against oral transmission. If chlorhexidine, a usual component of mouth rinse, is not efficient to kill SARS-CoV-2, the use of a mouth rinses and/or with local nasal applications that contain β-cyclodextrins combined with flavonoids agents, such as Citrox, could provide valuable adjunctive treatment to reduce the viral load of saliva and nasopharyngeal microbiota, including potential SARS-CoV-2 carriage. We urge national agencies and authorities to start clinical trials to evaluate the preventive effects of βCD-Citrox therapeutic oral biofilm rinses in reducing the viral load of the infection and possibly disease progression.

Mots clés: COVID-19; 2019-nCoV; SARS-CoV-2; oral cavity; mouthrinse; β-cyclodextrins; Citrox; viral load; microbiome

Domaines: Maladies infectieuses

Florence Carrouel, Maria Conte, Julian Fisher, Lucio Souza Gonçalves, Claude Dussart, et al.. COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression. Journal of Clinical Medicine, 2020, 2020, ⟨10.3390/jcm9041126⟩. ⟨hal-02545367⟩