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COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression

Abstract : Considered to be a major portal of entry for infectious agents, the oral cavity is directly associated with the evolutionary process of SARS-CoV-2 in its inhalation of ambient particles in the air and in expectorations. Some new generations of mouth rinses currently on the market have ingredients that could contribute to lower the SARS-CoV-2 viral load, and thus facilitate the fight against oral transmission. If chlorhexidine, a usual component of mouth rinse, is not efficient to kill SARS-CoV-2, the use of a mouth rinses and/or with local nasal applications that contain β-cyclodextrins combined with flavonoids agents, such as Citrox, could provide valuable adjunctive treatment to reduce the viral load of saliva and nasopharyngeal microbiota, including potential SARS-CoV-2 carriage. We urge national agencies and authorities to start clinical trials to evaluate the preventive effects of βCD-Citrox therapeutic oral biofilm rinses in reducing the viral load of the infection and possibly disease progression.
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https://hal-univ-lyon1.archives-ouvertes.fr/hal-02545367
Contributor : Florence Carrouel <>
Submitted on : Friday, April 17, 2020 - 7:50:18 AM
Last modification on : Tuesday, October 20, 2020 - 10:57:15 AM

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Florence Carrouel, Maria Conte, Julian Fisher, Lucio Gonçalves, Claude Dussart, et al.. COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression. Journal of Clinical Medicine, MDPI, 2020, 2020, ⟨10.3390/jcm9041126⟩. ⟨hal-02545367⟩

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