Cytotoxic and antiplasmodial xanthones from Pentadesma butyracea

F. Zelefack , David Guilet (1) , Nelly Fabre , Christine Bayet (1) , S. Chevalley , S. Ngouela , B.N. Lenta , A. Valentin , E. Tsamo , Marie-Genevieve Dijoux-Franca (1)

1 LEM - Laboratoire d'Ecologie Microbienne - UMR 5557

Four new xanthones, butyraxanthones A?D (1?4), were isolated from the stem bark of Pentadesma butyracea, together with six known xanthones (5?10) and a triterpenoid (lupeol). The structures of 1?4 were established by spectroscopic methods. Compounds 1?10 were tested in vitro for antiplasmodial activity against a Plasmodium falciparum chloroquine-resistant strain and for cytotoxicity against a human breast cancer cell line (MCF-7). Nearly all of these xanthones exhibited good antiplasmodial activity, and some of them also demonstrated potent cytotoxicity. Four new xanthones, butyraxanthones A?D (1?4), were isolated from the stem bark of Pentadesma butyracea, together with six known xanthones (5?10) and a triterpenoid (lupeol). The structures of 1?4 were established by spectroscopic methods. Compounds 1?10 were tested in vitro for antiplasmodial activity against a Plasmodium falciparum chloroquine-resistant strain and for cytotoxicity against a human breast cancer cell line (MCF-7). Nearly all of these xanthones exhibited good antiplasmodial activity, and some of them also demonstrated potent cytotoxicity.

Domaines: Sciences du Vivant [q-bio]

F. Zelefack, David Guilet, Nelly Fabre, Christine Bayet, S. Chevalley, et al.. Cytotoxic and antiplasmodial xanthones from Pentadesma butyracea. Journal of Natural Products, 2009, 72 (5), pp.954-957. ⟨10.1021/np8005953⟩. ⟨hal-02545049⟩