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Selective modulation of P-glycoprotein activity by steroidal saponines from Paris polyphylla

Abstract : Bio-guided fractionation of the roots of Paris polyphylla (Trilliaceae), based on inhibition of P-glycoprotein-mediated daunorubicin efflux in K562/R7 cell line, led to isolation and identification of the three saponins 3-O-Rha(12)[Ara(14)]Glc-pennogenine, gracillin and polyphyllin D, and the two ecdysteroids 20-hydroxyecdysone and pinnatasterone. These compounds were tested for multidrug reversion on P-glycoprotein (ABCB1) with both drug-selected and transfected cell lines, and also on Breast Cancer Resistance Protein (BCRP/ABCG2). By contrast to a weak efficiency on BCRP, the three saponins displayed significant effects as inhibitors of P-glycoprotein-mediated drug efflux.
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https://hal-univ-lyon1.archives-ouvertes.fr/hal-02545047
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Submitted on : Thursday, April 16, 2020 - 5:20:00 PM
Last modification on : Friday, April 17, 2020 - 2:39:25 PM

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Van.T.Hi Bao Nguyen, Nicole Darbour, Christine Bayet, A. Doreau, Imad Raad, et al.. Selective modulation of P-glycoprotein activity by steroidal saponines from Paris polyphylla. Fitoterapia, Elsevier, 2009, 80 (1), pp.39-42. ⟨10.1016/j.fitote.2008.09.010⟩. ⟨hal-02545047⟩

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