Skip to Main content Skip to Navigation
New interface
Journal articles

Flavonoids products from Nitraria retusa leaves promote lymphoblastoid cells apoptosis

Abstract : In this report, the ethyl acetate extract and its major constituent, isorhamnetin 3-o-robinobioside (I3-O-Rob), from Nitraria retusa (N. Retusa) leaf extracts were evaluated for their ability to induce apoptosis in human lymphoblastoid cells (TK6). Apoptosis of TK6 cell line was carried out using DNA fragmentation, poly ADP-ribose polymerase (PARP) cleavage with reference to caspase-3 activity. These tested products, from N. Retusa, enhanced the apoptosis effects in the tested cancer cell line. This result was confirmed by DNA fragmentation and PARP cleavage indicating a release of caspase-3 level. Our results indicate that the original ethyl acetate extract and the I3-O-Rob have a great antiproliferative effect on human lymphoblastoid cells (TK6), which may be due to their involvement in the apoptotic pathway.
Document type :
Journal articles
Complete list of metadata
Contributor : Depot 1 Lyon 1 Connect in order to contact the contributor
Submitted on : Monday, April 6, 2020 - 9:38:02 AM
Last modification on : Saturday, June 25, 2022 - 9:25:34 PM




J. Boubaker, W. Bhouri, M. Ben Sghaier, I. Bouhlel, M. Krifa, et al.. Flavonoids products from Nitraria retusa leaves promote lymphoblastoid cells apoptosis. Nutrition and Cancer, 2012, 64 (7), pp.1095-1102. ⟨10.1080/01635581.2012.717680⟩. ⟨hal-02532819⟩



Record views