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Journal articles
MicroRNAs in pituitary tumors
Abstract : Since the presence of microRNAs was first observed in normal pituitary, the majority of scientific publications addressing their role and the function of microRNAs in the pituitary have been based on pituitary tumor studies. In this review, we briefly describe the involvement of microRNAs in the synthesis of pituitary hormones and we present a comprehensive inventory of microRNA suppressors and inducers of pituitary tumors. Finally, we summarize the functional role of microRNAs in tumorigenesis, progression and aggressiveness of pituitary tumors, mechanisms contributing to the regulation (transcription factors, genomic modifications or epigenetic) or modulation (pharmacological treatment) of microRNAs in these tumors, and the interest of thoroughly studying the expression of miRNAs in body fluids.
Keywords :
microRNAs
Pituitary tumors
https://hal-univ-lyon1.archives-ouvertes.fr/hal-02487203
Contributor : Depot 1 Lyon 1 Connect in order to contact the contributor
Submitted on : Friday, February 21, 2020 - 2:14:00 PM
Last modification on : Friday, January 7, 2022 - 3:51:20 AM
Contributor : Depot 1 Lyon 1 Connect in order to contact the contributor
Submitted on : Friday, February 21, 2020 - 2:14:00 PM
Last modification on : Friday, January 7, 2022 - 3:51:20 AM