 |
Journal articles
Advancing Solutions to the Carbohydrate Sequencing Challenge
Christopher Gray
1
Lukasz Migas
1
Perdita Barran
1
Kevin Pagel
2
Peter Seeberger
3
Claire Eyers
4
Geert-Jan Boons
5
Nicola Pohl
6
Isabelle Compagnon
7
Göran Widmalm
8
Sabine Flitsch
1
7
DYNAMO - Structure et dynamique multi-échelle des édifices moléculaires
ILM - Institut Lumière Matière [Villeurbanne]
1
University of Manchester [Manchester] (Oxford Rd, Manchester M13 9PL - United Kingdom)
2
Freie Universität Berlin (Kaiserswerther Str. 16-18, 14195 Berlin - Germany)
3
Department of Biomolecular Systems [Potsdam] (Am Mühlenberg 1 D-14476 Potsdam - Germany)
- Max Planck Institute of Colloids and Interfaces (Am Mühlenberg 1, 14476 Potsdam
- Germany)
- Max-Planck-Gesellschaft (Jägerstrasse, 10-11, D-10117 Berlin - Germany)
4
University of Liverpool (Liverpool L69 3BX, United Kingdom
- United Kingdom)
5
University of Georgia [USA] (Athens, GA 30602 - United States)
6
Indiana University [Bloomington] (107 S. Indiana Avenue, Bloomington, IN 47405-7000 - United States)
- Indiana University System (United States)
7
DYNAMO - Structure et dynamique multi-échelle des édifices moléculaires (France)
- ILM - Institut Lumière Matière [Villeurbanne] (UMR5306 CNRS Université Claude Bernard Lyon 1 Domaine Scientifique de La Doua Bâtiment Kastler, 10 rue Ada Byron 69622 Villeurbanne CEDEX, Franc - France)
- UCBL - Université Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
- Université de Lyon (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5306 (France)
- UCBL - Université Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
8
Stockholm University (Stockholm University, SE-106 91 Stockholm, Sweden - Sweden)
Abstract : Carbohydrates possess a variety of distinct features with stereochemistry playing a particularly important role in distinguishing their structure and function. Monosaccharide building blocks are defined by a high density of chiral centers. Additionally, the anomericity and regiochemistry of the glycosidic linkages carry important biological information. Any carbohydrate-sequencing method needs to be precise in determining all aspects of this stereodiversity. Recently, several advances have been made in developing fast and precise analytical techniques that have the potential to address the stereochemical complexity of carbohydrates. This perspective seeks to provide an overview of some of these emerging techniques, focusing on those that are based on NMR and MS-hybridized technologies including ion mobility spectrometry and IR spectroscopy.
Document type :
Journal articles
Complete list of metadatas
https://hal-univ-lyon1.archives-ouvertes.fr/hal-02365096
Contributor : Armelle Vidal <>
Submitted on : Friday, November 15, 2019 - 11:55:20 AM
Last modification on : Thursday, October 15, 2020 - 8:54:05 AM
Contributor : Armelle Vidal <>
Submitted on : Friday, November 15, 2019 - 11:55:20 AM
Last modification on : Thursday, October 15, 2020 - 8:54:05 AM
Links full text
Identifiers
- HAL Id : hal-02365096, version 1
- DOI : 10.1021/jacs.9b06406
Collections
UNIV-LYON1 | CNRS | ILM | UDL
Citation
Christopher Gray, Lukasz Migas, Perdita Barran, Kevin Pagel, Peter Seeberger, et al.. Advancing Solutions to the Carbohydrate Sequencing Challenge. Journal of the American Chemical Society, American Chemical Society, 2019, 141 (37), pp.14463-14479. ⟨10.1021/jacs.9b06406⟩. ⟨hal-02365096⟩
Metrics
Record views