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Advancing Solutions to the Carbohydrate Sequencing Challenge

Christopher Gray 1 Lukasz Migas 1 Perdita Barran 1 Kevin Pagel 2 Peter Seeberger 3 Claire Eyers 4 Geert-Jan Boons 5 Nicola Pohl 6 Isabelle Compagnon 7 Göran Widmalm 8 Sabine Flitsch 1
1 University of Manchester [Manchester]
2 Freie Universität Berlin
3 Department of Biomolecular Systems [Potsdam]
4 University of Liverpool
5 University of Georgia [USA]
6 Indiana University [Bloomington]
7 DYNAMO - Structure et dynamique multi-échelle des édifices moléculaires
ILM - Institut Lumière Matière [Villeurbanne]
8 Stockholm University
Abstract : Carbohydrates possess a variety of distinct features with stereochemistry playing a particularly important role in distinguishing their structure and function. Monosaccharide building blocks are defined by a high density of chiral centers. Additionally, the anomericity and regiochemistry of the glycosidic linkages carry important biological information. Any carbohydrate-sequencing method needs to be precise in determining all aspects of this stereodiversity. Recently, several advances have been made in developing fast and precise analytical techniques that have the potential to address the stereochemical complexity of carbohydrates. This perspective seeks to provide an overview of some of these emerging techniques, focusing on those that are based on NMR and MS-hybridized technologies including ion mobility spectrometry and IR spectroscopy.
Keywords : Glycan Carbohydrate NMR mass spectrometry liquid chromatography ion-mobility spectrometry infrared spectroscopy
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https://hal-univ-lyon1.archives-ouvertes.fr/hal-02365096
Contributor : Armelle Vidal <>
Submitted on : Wednesday, January 20, 2021 - 9:50:34 AM
Last modification on : Wednesday, January 20, 2021 - 1:04:38 PM

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Christopher Gray, Lukasz Migas, Perdita Barran, Kevin Pagel, Peter Seeberger, et al.. Advancing Solutions to the Carbohydrate Sequencing Challenge. Journal of the American Chemical Society, American Chemical Society, 2019, 141 (37), pp.14463-14479. ⟨10.1021/jacs.9b06406⟩. ⟨hal-02365096⟩

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