A Pre-Clinical MRI Solution to Quantitatively Map Gadolinium Nanoparticles for Radiotherapy Enhancement Studies

P. Chaipanichkul 1 B. Siow 2, 3 G. Royle 1 Olivier Tillement 4 K. Ricketts 2
1 UCL - Department of Medical Physics and Biomedical Engineering
2 UCL - University College of London [London]
3 The Francis Crick Institute
4 ILM - Institut Lumière Matière [Villeurbanne]
Abstract : Gadolinium nanoparticles (GdNPs) have been used in image-guided radiotherapy and as radiosensitisers in radiation therapy. To understand the full potential of the pre-clinical study of GdNPs in radiotherapy, accurate localisation and quantification of NP concentration are crucial. This research was carried out to optimise pre-clinical MRI imaging parameters and characterise MRI performance for the quantification of GdNP concentration that is currently under investigation for radiotherapy enhancement.
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https://hal-univ-lyon1.archives-ouvertes.fr/hal-02363535
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Submitted on : Thursday, November 14, 2019 - 2:31:02 PM
Last modification on : Monday, February 17, 2020 - 11:50:38 AM

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P. Chaipanichkul, B. Siow, G. Royle, Olivier Tillement, K. Ricketts. A Pre-Clinical MRI Solution to Quantitatively Map Gadolinium Nanoparticles for Radiotherapy Enhancement Studies. International Journal of Radiation Oncology - Biology - Physics, Elsevier, 2019, 105 (1), pp.E779. ⟨10.1016/j.ijrobp.2019.06.736⟩. ⟨hal-02363535⟩

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