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Journal articles
Comparative genomic analysis identifies small open reading frames (sORFs) with peptide-encoding features in avian 16S rDNA
Abstract : The mitochondrial genome (mt-DNA) functional repertoire has recently been enriched in mammals by the identification of functional small open reading frames (sORFs) embedded in ribosomal DNAs. Through com- parative genomic analyses the presence of putatively functional sORFs was investigated in birds. Alignment of available avian mt-DNA sequences revealed highly conserved regions containing four putative sORFs that pre- sented low insertion/deletion polymorphism rate (< 0.1%) and preserved in frame start/stop codons in > 80% of species. Detected sORFs included avian homologs of human Humanin and Short-Humanin-Like-Peptide 6 and two new sORFs not yet described in mammals. The amino-acid sequences of the four putative encoded peptides were strongly conserved among birds, with amino-acid p-distances (5.6 to 25.4%) similar to those calculated for typical avian mt-DNA-encoded proteins (14.8%). Conservation resulted from either drastic conservation of the nucleotide sequence or negative selection pressure. These data extend to birds the possibility that mitochondrial rDNA may encode small bioactive peptides.
https://hal-univ-lyon1.archives-ouvertes.fr/hal-02345550
Contributor : Nathalie Lyvet <>
Submitted on : Monday, November 4, 2019 - 3:32:24 PM
Last modification on : Thursday, May 14, 2020 - 2:30:22 PM
Contributor : Nathalie Lyvet <>
Submitted on : Monday, November 4, 2019 - 3:32:24 PM
Last modification on : Thursday, May 14, 2020 - 2:30:22 PM
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