Cross sectional study on prevalence of sickle cell alleles S and C among patients with mild malaria in Ivory Coast

Stephane Koui Tossea (1) , Eric Gbessi Adji (1) , Baba Coulibaly (1) , Berenger Ako Ako (1) , David Ngolo Coulibaly (1) , Philippe Joly (2, 3) , Serge-Brice Assi (4, 5) , Andre O Touré (1) , Ronan Jambou (1, 6)

1 Institut Pasteur de Côte d'Ivoire
2 LIBM - Laboratoire Interuniversitaire de Biologie de la Motricité
3 Unité de Pathologie Moléculaire du Globule Rouge
4 IPR - Institut Pierre Richet
5 Programme National de Lutte Contre le Paludisme [Côte d'Ivoire]
6 Département Parasites et Insectes vecteurs - Department of Parasites and Insect Vectors

Sickle cell anemia is due to a mutations on the betaglobin gene, inducing abnormal hemoglobin. In West Africa the main mutations lead to S or C types of hemoglobin. Patients with homozygote mutations seem protected against severe malaria, but not against mild disease. The prevalence of abnormal hemoglobin among patients attending dispensaries for mild malaria is thus unknown. A retrospective study was conducted to update data on the prevalence of S and C hemoglobin among patients attending dispensaries with mild malaria. Enrolment of patients was conducted during in vivo malaria treatment efficacy survey following the 42 days WHO protocol. A group of non-infected pregnant women and a group of patients with fever different from malaria, were also recruited in the same dispensaries.

Domaines: Sciences du Vivant [q-bio]

Stephane Koui Tossea, Eric Gbessi Adji, Baba Coulibaly, Berenger Ako Ako, David Ngolo Coulibaly, et al.. Cross sectional study on prevalence of sickle cell alleles S and C among patients with mild malaria in Ivory Coast. BMC Research Notes, 2018, 11 (1), ⟨10.1186/s13104-018-3296-7⟩. ⟨hal-02329338⟩