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Journal articles
Combining Time-of-Flight Secondary Ion Mass Spectrometry Imaging Mass Spectrometry and CARS Microspectroscopy Reveals Lipid Patterns Reminiscent of Gene Expression Patterns in the Wing Imaginal Disc of Drosophila melanogaster
Abstract : Using label-free ToF-SIMS imaging mass spectrometry, we generated a map of small molecules differentially expressed in the Drosophila wing imaginal disc. The distributions of these moieties were in line with gene expression patterns observed during wing imaginal disc development. Combining ToF-SIMS imaging and coherent anti-Stokes Raman spectroscopy (CARS) microspectroscopy allowed us to locally identify acylglycerols as the main constituents of the pattern differentiating the future body wall tissue from the wing blade tissue. The findings presented herein clearly demonstrate that lipid localization patterns are strongly correlated with a developmental gene expression. From this correlation, we hypothesize that lipids play a so far unrecognized role in organ development.
https://hal-univ-lyon1.archives-ouvertes.fr/hal-02317574
Contributor : Depot 3 Lyon 1 <>
Submitted on : Friday, January 22, 2021 - 11:42:28 AM
Last modification on : Wednesday, June 9, 2021 - 11:32:56 AM
Long-term archiving on: : Friday, April 23, 2021 - 7:01:51 PM
Contributor : Depot 3 Lyon 1 <>
Submitted on : Friday, January 22, 2021 - 11:42:28 AM
Last modification on : Wednesday, June 9, 2021 - 11:32:56 AM
Long-term archiving on: : Friday, April 23, 2021 - 7:01:51 PM
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acs.analchem.7b00125.pdf
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