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3D imaging of theranostic nanoparticles in mice organs by means of x-ray phase contrast tomography

Abstract : Theranostics is an innovative research field that aims to develop high target specificity cancer treatments by administering small metal-based nanoparticles (NPs). This new generation of compounds exhibits diagnostic and therapeutic properties due to the high atomic number of their metal component. In the framework of a combined research program on low dose X-ray imaging and theranostic NPs, X-ray Phase Contrast Tomography (XPCT) was performed at ESRF using a 3 μm pixel optical system on two samples: a mouse brain bearing melanoma metastases injected with gadolinium NPs and, a mouse liver injected with gold NPs. XPCT is a non-destructive technique suitable to achieve the 3D reconstruction of a specimen and, widely used at micro-scale to detect abnormalities of the vessels, which are associated to the tumor growth or to the development of neurodegenerative diseases. Moreover, XPCT represents a promising and complementary tool to study the biodistribution of theranostic NPs in biological materials, thanks to the strong contrast with respect to soft tissues that metal-based NPs provide in radiological images. This work is relied on an original imaging approach based on the evaluation of the contrast differences between the images acquired below and above K-edge energies, as a proof of the certain localization of NPs. We will present different methods aiming to enhance the localization of NPs and a 3D map of their distribution in large volume of tissues.
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Contributor : Marie-Gabrielle Chautard Connect in order to contact the contributor
Submitted on : Tuesday, October 15, 2019 - 11:31:44 AM
Last modification on : Saturday, September 24, 2022 - 2:30:05 PM

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Elena Longo, Alberto Bravin, Francesco Brun, Inna Bukreeva, Alessia Cedola, et al.. 3D imaging of theranostic nanoparticles in mice organs by means of x-ray phase contrast tomography. Physics of Medical Imaging, Feb 2018, Houston, United States. pp.167, ⟨10.1117/12.2293090⟩. ⟨hal-02316354⟩



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