Skip to Main content Skip to Navigation
Journal articles

Magnetic Flattening of Stem-Cell Spheroids Indicates a Size-Dependent Elastocapillary Transition

Abstract : Cellular aggregates (spheroids) are widely used in biophysics and tissue engineering as model systems for biological tissues. In this Letter we propose novel methods for molding stem-cell spheroids, deforming them, and measuring their interfacial and elastic properties with a single method based on cell tagging with magnetic nanoparticles and application of a magnetic field gradient. Magnetic molding yields spheroids of unprecedented sizes (up to a few mm in diameter) and preserves tissue integrity. On subjecting these spheroids to magnetic flattening (over 150g), we observed a sizedependent elastocapillary transition with two modes of deformation: liquid-drop-like behavior for small spheroids, and elastic-sphere-like behavior for larger spheroids, followed by relaxation to a liquidlike drop.
Document type :
Journal articles
Complete list of metadata
Contributor : Depot 4 Lyon 1 Connect in order to contact the contributor
Submitted on : Tuesday, February 16, 2021 - 2:10:28 PM
Last modification on : Saturday, November 27, 2021 - 11:24:09 AM
Long-term archiving on: : Monday, May 17, 2021 - 7:41:32 PM


Publisher files allowed on an open archive




Francois Mazuel, Myriam Reffay, Vicard Du, Jean-Claude Bacri, Jean-Paul Rieu, et al.. Magnetic Flattening of Stem-Cell Spheroids Indicates a Size-Dependent Elastocapillary Transition. Physical Review Letters, American Physical Society, 2015, 114, pp.098105. ⟨10.1103/PhysRevLett.114.098105⟩. ⟨hal-02307262⟩



Les métriques sont temporairement indisponibles