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Journal articles
Magnetic Flattening of Stem-Cell Spheroids Indicates a Size-Dependent Elastocapillary Transition
Abstract : Cellular aggregates (spheroids) are widely used in biophysics and tissue engineering as model systems for biological tissues. In this Letter we propose novel methods for molding stem-cell spheroids, deforming them, and measuring their interfacial and elastic properties with a single method based on cell tagging with magnetic nanoparticles and application of a magnetic field gradient. Magnetic molding yields spheroids of unprecedented sizes (up to a few mm in diameter) and preserves tissue integrity. On subjecting these spheroids to magnetic flattening (over 150g), we observed a sizedependent elastocapillary transition with two modes of deformation: liquid-drop-like behavior for small spheroids, and elastic-sphere-like behavior for larger spheroids, followed by relaxation to a liquidlike drop.
https://hal-univ-lyon1.archives-ouvertes.fr/hal-02307262
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Submitted on : Tuesday, February 16, 2021 - 2:10:28 PM
Last modification on : Saturday, November 27, 2021 - 11:24:09 AM
Long-term archiving on: : Monday, May 17, 2021 - 7:41:32 PM
Contributor : Depot 4 Lyon 1 Connect in order to contact the contributor
Submitted on : Tuesday, February 16, 2021 - 2:10:28 PM
Last modification on : Saturday, November 27, 2021 - 11:24:09 AM
Long-term archiving on: : Monday, May 17, 2021 - 7:41:32 PM
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