Skip to Main content Skip to Navigation
Journal articles

Phase-field modelling of the dynamics of Z-ring formation in liposomes: Onset of constriction and coarsening

Abstract : We propose a model for the dynamics of the formation of rings of FtsZ on tubular liposomes which produce constriction on the corresponding membrane. Our phase-field model is based on a simple bending energy that captures the dynamics of the interplay between the protein and the membrane. The short-time regime is analyzed by a linear dispersion relation, with which we are able to predict the number of rings per unit length on a tubular liposome. We study numerically the long-time dynamics of the system in the non-linear regime where we observe coarsening of Z-rings on tubular liposomes. In particular, our numerical results show that, during the coarsening process, the number of Z-rings decreases as the radius of tubular liposome increases. This is consistent with the experimental observation that the separation between rings is proportional to the radius of the liposome. Our model predicts that the mechanism for the increased rate of coarsening in liposomes of larger radius is a consequence of the increased interface energy.
Document type :
Journal articles
Complete list of metadata

https://hal-univ-lyon1.archives-ouvertes.fr/hal-02305591
Contributor : Depot 4 Lyon 1 <>
Submitted on : Monday, February 22, 2021 - 8:56:34 AM
Last modification on : Monday, March 29, 2021 - 11:50:04 AM
Long-term archiving on: : Sunday, May 23, 2021 - 6:14:56 PM

File

Picallo2015_Article_Phase-fiel...
Publication funded by an institution

Identifiers

Collections

Citation

Clara B. Picallo, R. A. Barrio, C. Varea, T. Alarcon, A. Hernandez-Machado. Phase-field modelling of the dynamics of Z-ring formation in liposomes: Onset of constriction and coarsening. European Physical Journal E: Soft matter and biological physics, EDP Sciences: EPJ, 2015, 38 (6), pp.61. ⟨10.1140/epje/i2015-15061-0⟩. ⟨hal-02305591⟩

Share

Metrics

Record views

77

Files downloads

30