T. P. Singh and O. M. Singh, Mini-Rev. Med. Chem, vol.18, pp.9-25, 2018.

). D. Sunil and P. R. Kamath, Curr. Top. Med. Chem, vol.134, p.959, 2017.

J. A. Homer, J. Sperry, J. ;. Nat, S. L. Sravanthi, and . Manju, Eur. J. Pharm. Sci, vol.80, pp.421-441, 2015.

S. W. Youn and T. Y. Ko, Asian J. Org. Chem, vol.7, pp.1467-1487, 2018.

G. Frost, Org. Biomol. Chem, vol.7, pp.3550-3567, 2017.

Y. Chen, Z. Xie, Y. Huaxue, ;. M. Bandini-;-m.-platon, R. Amardeil et al., Org. Biomol. Chem, vol.32, pp.3929-3968, 2012.

M. Shiri-;-b, ). A. Palmieri, M. Petrini, and R. R. Shaikh, Org. Biomol. Chem, vol.112, pp.1259-1270, 2010.

). Y. Gu, W. Huang, S. Chen, X. Wang, ;. Wu et al., Org. Lett, vol.20, pp.4285-4289, 2018.

J. Yang, Y. Gu, ;. Liu, W. Huang, M. Wang et al., Adv. Synth. Catal, vol.360, 2018.

B. Gu-;-d)-l.-min, Y. Pan, and . Gu, Adv. Synth. Catal, vol.358, pp.364-367, 2016.

C. Liu, L. Zhou, D. Jiang, Y. Gu, ;. M. Li et al., Asian J. Org. Chem, vol.5, pp.2484-2494, 2012.

R. K. Henderson, C. Jiménez-gonzález, D. J. Constable, S. R. Alston, G. G. Inglis et al., , vol.13, pp.4546-4551, 2011.

C. Vaccaro, ). S. Santoro, F. Ferlin, L. Luciani, L. Ackermann et al., Eur. J, vol.24, pp.1601-1612, 2017.

S. Mcelroy, P. J. Abou-shehada, G. Dunn, . P. Chem-;-f)-f, S. Byrne et al., Sustainable Chem. Proc. 2016, 4, vol.18, pp.288-296, 2016.

J. D. Koenig, M. R. Hayler, S. Hickey, M. E. Hughes, G. Kopach et al., Green Chem, vol.20, pp.5082-5103, 2018.

). R. Sheldon, Chem. Soc. Rev, vol.41, pp.1437-1451, 2012.

). J. Yang, F. Mei, S. Fu, Y. Gu, G. Chem-;-c et al., , vol.20, pp.1032-1037, 2016.

Y. Ren, M. Li, J. Yang, J. Peng, and Y. Gu, Adv. Synth. Catal, vol.353, pp.3473-3484, 2011.

J. Sherwood, M. De-bruyn, A. Constantinou, L. Moity, C. R. Mcelroy et al., ACS Sustainable Chem. Eng, vol.50, pp.4423-4427, 2014.

C. Murray, A. J. Jamieson, and . Watson, Org. Biomol. Chem, vol.16, pp.2851-2854, 2018.

C. R. Sherwood, A. J. Mcelroy, ;. Hunt, K. Mistry, and T. Mapesa, Green Chem, vol.20, pp.136-140, 2018.

W. Bousfield, J. E. Camp, and G. Chem, g) J. E. Camp, ChemSusChem, vol.19, pp.3048-3055, 2017.

J. Sherwood, H. L. Parker, K. Moonen, T. J. Farmer, A. J. Hunt et al., , vol.14, pp.3990-3996, 2016.

E. Petricci, C. Risi, F. Ferlin, D. Lanari, and L. Vaccaro, 10571. b) F. Ferlin, L, vol.8, 2018.

S. Luciani, A. Santoro, D. Marrocchi, A. Lanari, L. Bechtoldt et al., , vol.20, pp.1601-1612, 2017.

L. Facchetti, . Vaccaro, ;. G. Green-chem, L. Strappaveccia, E. Luciani et al., , vol.17, pp.1071-1076, 2015.

S. G. Koenig, J. W. Dankwardt, Y. Liu, H. Zhao, and S. P. Singh, ACS Sustainable Chem. Eng, 1359.

A. Duereh, Y. Sato, R. L. Smith, and H. Inomata, Org. Process Res. Dev, vol.21, pp.114-124, 2017.

N. A. Isley, R. T. Linstadt, S. M. Kelly, F. Gallou, and B. H. Lipshutz, Org. Process Res. Dev, vol.17, pp.218-221, 2015.

K. Zhang, X. Li, S. Chen, H. Xu, J. Deng et al., ChemSusChem, vol.11, pp.726-734, 2018.

A. Taheri, X. Pan, C. Liu, Y. Gu-;-b, ). A. Taheri et al., ChemSusChem, vol.7, pp.479-488, 2014.

Q. Sun, S. Wang, B. Aguila, X. Meng, S. Ma et al., Nature Commun, vol.9, p.3236, 2018.

A. C. Cole, J. L. Jensen, I. Ntai, K. L. Tran, K. J. Weaver et al., J. Am. Chem. Soc, vol.124, pp.5962-5963, 2002.

G. He, J. Yuan, H. Zhu, K. Wei, L. Wang et al., Bioorg. Med. Chem. Lett, vol.27, pp.1323-1327, 2013.

C. Chen, L. Liu, D. Yang, D. Wang, and Y. Chen, Mol. Divers, vol.20, pp.619-626, 2005.

C. Cheng, C. Liu, and Y. Gu, Tetrahedron, vol.71, pp.8009-8017, 2015.

H. J. Knölker, K. R. Reddy-;-b)-a, K. R. Schmidt, H. J. Reddy, ). J. Knölker-;-c et al., Chem. Soc. Rev, vol.102, pp.345-361, 2002.

B. Robinson-;-b, ). S. Muller, M. J. Webber, B. P. List-;-c)-v, K. K. Kumar et al., Angew. Chem., Int. Ed, vol.69, pp.2701-2705, 1969.

C. Kashima, S. Hibi, T. Maruyama, and Y. Omote, Tetrahedron Lett, vol.27, pp.2131-2134, 1986.

Y. Kuroki, J. Tsunashima, . Heterocycl, ). Y. Chem, S. Matsuda et al., Chem. -Eur. J, vol.18, pp.6383-6457, 1981.

Y. Matsuda, S. Naoe, S. Oishi, N. Fujii, H. Ohno et al., Chem. -Eur. J, vol.21, pp.4010-4014, 2009.

). J. Stepherson, C. E. Ayala, T. H. Tugwell, J. L. Henry, F. R. Fronczek et al.,

). J. Lett-;-k, Z. Wu, S. Yang, C. Zhang, Q. Jiang et al., , vol.18, pp.3002-3005, 2016.

. Catal-;-l)-a, P. Suárez, M. A. García-garcía, R. Fernández-rodríguez, and . Sanz, Adv. Synth. Catal, vol.5, pp.374-382, 2014.

R. Garzelli, S. Samaritani, and C. Malanga, Tetrahedron, vol.64, pp.4183-4186, 2008.

J. Baussanne, ;. Royer, S. Malanga, and . Mannucci, Tetrahedron Lett, vol.27, pp.2023-2025, 1997.

M. Li, J. Yang, and Y. Gu, Adv. Synth. Catal, vol.353, pp.142-183, 2011.

C. Liu, Y. Gu, ;. Liu, B. Pan, Y. Gu et al., Adv. Synth. Catal, vol.358, pp.979-986, 2016.

G. Ranjani?r and . Nagarajan, Org. Lett, 2019.

, Compound 9a is not commercially available, and and can be synthesized via a two-step method, Chem. Commun, vol.12, pp.1408-1409, 2003.

C. Gao, Y. Sun, D. Cui, Y. Bi, W. S. Li-;-h et al., Faming Zhuanli Shenqing, Tetrahedron, vol.73, pp.1413-1423, 2016.

, Table 1. Three-component reaction of 4a, 5a and 6a under different conditions a, vol.32