Nonspecific interstitial pneumonia: time to be more specific? - Université Claude Bernard Lyon 1 Accéder directement au contenu
Article Dans Une Revue Current Opinion in Pulmonary Medicine Année : 2016

Nonspecific interstitial pneumonia: time to be more specific?

A. U. Wells
  • Fonction : Auteur
  • PersonId : 1018558

Résumé

PURPOSE OF REVIEW: There is growing speculation that idiopathic nonspecific interstitial pneumonia (NSIP) is, in reality, a grouping of separate disorders with a common histologic pattern. In this review, distinct clinical, imaging, and serologic features providing support for this premise are detailed and discussed. RECENT FINDINGS: The diagnosis of idiopathic NSIP is often uncertain because of its clinical and imaging diversity. In a landmark study of inter-multidisciplinary group diagnostic variation, there were striking discrepancies between seven expert groups (kappa = 0.24) in diagnoses of idiopathic NSIP. Recent histologic observations provide support for the concept of an NSIP/organizing pneumonia overlap, distinct from isolated NSIP. An important group of NSIP patients with features of 'undifferentiated connective disease', historically classified as an idiopathic NSIP subgroup, have been shown to have a lower mortality than idiopathic NSIP patients without features of autoimmune disease. The recently proposed entity of 'interstitial pneumonia with autoimmune features' includes many patients with a histologic or imaging pattern of NSIP, shown by Oldham and colleagues to have a similar survival to patients with connective tissue disease-related NSIP. SUMMARY: The concept of idiopathic NSIP as a grouping of separate disorders with a common histologic pattern provides a template for potentially important pathogenetic insights.
Fichier non déposé

Dates et versions

hal-02192924 , version 1 (24-07-2019)

Identifiants

Citer

A. U. Wells, Vincent Cottin. Nonspecific interstitial pneumonia: time to be more specific?. Current Opinion in Pulmonary Medicine, 2016, 22 (5), pp.450-5. ⟨10.1097/MCP.0000000000000302⟩. ⟨hal-02192924⟩
12 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More