R. J. Pomerantz, Reservoirs of human immunodeficiency virus type 1: the main obstacles to viral eradication, Clin Infect Dis, vol.34, pp.91-97, 2002.

A. Flemming, Vaccines: HIV vaccine failure due to induction of immune suppressors?, Nat Rev Drug Discov, vol.13, pp.574-575, 2014.

H. P. Kiem, . Jerome, . Kr, ,. Deeks, . Sg et al., Hematopoietic-stem-cellbased gene therapy for HIV disease, Cell Stem Cell, vol.10, pp.137-147, 2012.

G. E. Ringpis, S. Shimizu, H. Arokium, J. Camba-colón, . Carroll et al., Engineering HIV-1-resistant T-cells from short-hairpin RNA-expressing hematopoietic stem/progenitor cells in humanized BLT mice, PLoS ONE, vol.7, p.53492, 2012.

A. Michienzi, S. Li, . Zaia, and J. J. Rossi, A nucleolar TAR decoy inhibitor of HIV-1 replication, Proc Natl Acad Sci, vol.99, pp.14047-14052, 2002.

J. Yuan, J. Wang, K. Crain, C. Fearns, K. A. Kim et al., Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichment, Mol Ther, vol.20, pp.849-859, 2012.

N. Holt, J. Wang, K. Kim, G. Friedman, X. Wang et al., Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo, Nat Biotechnol, vol.28, pp.839-847, 2010.

J. Bai, J. Sui, . Zhu, . Ry, . Tallarico et al., Inhibition of Tatmediated transactivation and HIV-1 replication by human anti-hCyclinT1 intrabodies, J Biol Chem, vol.278, pp.1433-1442, 2003.

M. Bouhamdan, . Strayer, . Ds, D. Wei, M. Mukhtar et al., Inhibition of HIV-1 infection by down-regulation of the CXCR4 co-receptor using an intracellular single chain variable fragment against CXCR4, Gene Ther, vol.8, pp.408-418, 2001.

C. H. Swan, B. Bühler, P. Steinberger, . Tschan, . Mp et al., BE, 2006.

, T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery, Gene Ther, vol.13, pp.1480-1492

E. M. Westerhout, M. Ooms, M. Vink, . Das, and B. Berkhout, HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome, Nucleic Acids Res, vol.33, pp.796-804, 2005.

T. Brady, . Agosto, . Lm, N. Malani, . Berry et al., HIV integration site distributions in resting and activated CD4+ T cells infected in culture, AIDS, vol.23, pp.1461-1471, 2009.

A. L. Marschall, A. Frenzel, T. Schirrmann, . Schüngel, and S. Dübel, Targeting antibodies to the cytoplasm, MAbs, vol.3, pp.3-16, 2011.

S. Sakkhachornphop, . Barbas, R. Keawvichit, . Wongworapat, and C. Tayapiwatana, Zinc finger protein designed to target 2-long terminal repeat junctions interferes with human immunodeficiency virus integration, Hum Gene Ther, vol.23, pp.932-942, 2012.

S. Sakkhachornphop, S. Jiranusornkul, K. Kodchakorn, S. Nangola, . Sirisanthana et al., Designed zinc finger protein interacting with the HIV-1 integrase recognition sequence at 2-LTR-circle junctions, Protein Sci, vol.18, pp.2219-2230, 2009.

M. A. Andrade, . Perez-iratxeta, and C. P. Ponting, Protein repeats: structures, functions, and evolution, J Struct Biol, vol.134, pp.117-131, 2001.

H. K. Binz, . Stumpp, . Mt, P. Forrer, . Amstutz et al., Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins, J Mol Biol, vol.332, pp.489-503, 2003.

S. Nangola, . Minard, and C. Tayapiwatana, Appraisal of translocation pathways for displaying ankyrin repeat protein on phage particles, Protein Expr Purif, vol.74, pp.156-161, 2010.

S. Nangola, A. Urvoas, M. Valerio-lepiniec, W. Khamaikawin, S. Sakkhachornphop et al., Antiviral activity of recombinant ankyrin targeted to the capsid domain of HIV-1 Gag polyprotein, Retrovirology, vol.9, p.17, 2012.
URL : https://hal.archives-ouvertes.fr/hal-02642663

L. T. Bacheler, A. , E. D. Kudish, P. Baker, D. Bunville et al., Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy, Antimicrob Agents Chemother, vol.44, pp.2475-2484, 2000.

M. S. Wyand, The use of SIV-infected rhesus monkeys for the preclinical evaluation of AIDS drugs and vaccines, AIDS Res Hum Retroviruses, vol.8, pp.349-356, 1992.

W. Praditwongwan, P. Chuankhayan, S. Saoin, T. Wisitponchai, . Lee et al., Crystal structure of an antiviral ankyrin targeting the HIV-1 capsid and molecular modeling of the ankyrin-capsid complex, J Comput Aided Mol Des, vol.28, pp.869-884, 2014.
URL : https://hal.archives-ouvertes.fr/hal-02192917

D. W. Sammond, . Eletr, . Zm, C. Purbeck, . Kimple et al., Structure-based protocol for identifying mutations that enhance protein-protein binding affinities, J Mol Biol, vol.371, pp.1392-1404, 2007.

J. Van-lunzen, T. Glaunsinger, I. Stahmer, V. Baehr, V. Baum et al., Transfer of autologous gene-modified T cells in HIV-infected patients with advanced immunodeficiency and drug-resistant virus, Mol Ther, vol.15, pp.1024-1033, 2007.

B. L. Levine, . Bernstein, . Wb, . Aronson, . Ne et al., , 2002.

, Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection, Nat Med, vol.8, pp.47-53

N. Onlamoon, N. Plagman, K. A. Rogers, . Mayne, . Ae et al., Anti-CD3/28 mediated expansion of macaque CD4+ T cells is polyclonal and provides extended survival after adoptive transfer, J Med Primatol, vol.36, pp.206-218, 2007.

K. Schmitt, . Hill, . Ms, Z. Liu, A. Ruiz et al., Comparison of the replication and persistence of simian-human immunodeficiency viruses expressing Vif proteins with mutation of the SLQYLA or HCCH domains in macaques, Virology, vol.404, pp.187-203, 2010.

D. F. Jimenez, C. I. Lee, C. E. Shea, ,. Kohn, . Db et al., HIV-1-derived lentiviral vectors and fetal route of administration on transgene biodistribution and expression in rhesus monkeys, Gene Ther, vol.12, pp.821-830, 2005.

Z. Du, . Ilyinskii, . Po, K. Lally, . Desrosiers et al., A mutation in integrase can compensate for mutations in the simian immunodeficiency virus att site, J Virol, vol.71, pp.8124-8132, 1997.

A. Cara, . Maggiorella, . Mt, R. Bona, L. Sernicola et al., Circular viral DNA detection and junction sequence analysis from PBMC of SHIV-infected cynomolgus monkeys with undetectable virus plasma RNA, Virology, vol.324, pp.531-539, 2004.

Y. Zhu, G. Chen, F. Lv, X. Wang, J. et al., Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation, Proc Natl Acad Sci, vol.108, pp.15834-15839, 2011.

A. Schweizer, P. Rusert, L. Berlinger, . Ruprecht, . Cr et al., , 2008.

, CD4-specific designed ankyrin repeat proteins are novel potent HIV entry inhibitors with unique characteristics, PLoS Pathog, vol.4, p.1000109

P. Pugach, A. Krarup, A. Gettie, M. Kuroda, J. Blanchard et al., In vivo binding and retention of CD4-specific DARPin 57.2 in macaques, PLoS ONE, vol.5, p.12455, 2010.

A. Mann, N. Friedrich, A. Krarup, J. Weber, E. Stiegeler et al., , 2013.

, Conformation-dependent recognition of HIV gp120 by designed ankyrin repeat proteins provides access to novel HIV entry inhibitors, J Virol, vol.87, pp.5868-5881

B. Joos, M. Fischer, A. Schweizer, H. Kuster, J. Böni et al., Positive in vivo selection of the HIV-1 envelope protein gp120 occurs at surface-exposed regions, J Infect Dis, vol.196, pp.313-320, 2007.

C. A. Didigu, . Wilen, . Cb, J. Wang, J. Duong et al., Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection, Blood, vol.123, pp.61-69, 2014.

R. L. Contento, B. Molon, C. Boularan, T. Pozzan, S. Manes et al., CXCR4-CCR5: a couple modulating T cell functions, Proc Natl Acad Sci, vol.105, pp.10101-10106, 2008.

B. Molon, G. Gri, M. Bettella, C. Gómez-moutón, A. Lanzavecchia et al., T cell costimulation by chemokine receptors, Nat Immunol, vol.6, pp.465-471, 2005.

X. Qu, P. Wang, D. Ding, L. Li, H. Wang et al., Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells, Nucleic Acids Res, vol.41, pp.7771-7782, 2013.

P. Kurre, J. Morris, B. Thomasson, ,. Kohn, . Db et al., Scaffold attachment region-containing retrovirus vectors improve long-term proviral expression after transplantation of GFP-modified CD34+ baboon repopulating cells, Blood, vol.102, pp.3117-3119, 2003.

A. Astrakhan, . Sather, . Bd, . Ryu, . By et al., Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome, Blood, vol.119, pp.4395-4407, 2012.

K. M. Sullivan, . Shulman, . Hm, R. Storb, . Weiden et al., Chronic graft-versus-host disease in 52 patients: adverse natural course and successful treatment with combination immunosuppression, Blood, vol.57, pp.267-276, 1981.

L. A. Mcnamara and K. L. Collins, Hematopoietic stem/precursor cells as HIV reservoirs, Curr Opin HIV AIDS, vol.6, pp.43-48, 2011.

. Alexaki and B. Wigdahl, HIV-1 infection of bone marrow hematopoietic progenitor cells and their role in trafficking and viral dissemination, PLoS Pathog, vol.4, p.1000215, 2008.

H. Miyoshi, K. A. Smith, . Mosier, . De, . Verma et al., Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors, Science, vol.283, pp.682-686, 1999.

M. G. Lewis, S. Bellah, K. Mckinnon, J. Yalley-ogunro, P. M. Zack et al., Titration and characterization of two rhesus-derived SIVmac challenge stocks, AIDS Res Hum Retroviruses, vol.10, pp.213-220, 1994.

S. Byrareddy, S. Thorat, P. Sharma, G. Hemashettar, K. Matsuda et al., , 2013.

, Macrophage/microglia lineage-related R5-tropic simian-human immunodeficiency viruses as tools to induce and study HAND, J Neurovirol, vol.19, pp.17-17

N. B. Siddappa, J. D. Watkins, . Wassermann, . Kj, R. Song et al., R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models, PLoS ONE, vol.5, p.11689, 2010.

U. O'doherty, . Swiggard, . Wj, D. Jeyakumar, . Mcgain et al., A sensitive, quantitative assay for human immunodeficiency virus type 1 integration, J Virol, vol.76, pp.10942-10950, 2002.

L. M. Agosto, J. J. Yu, J. Dai, R. Kaletsky, . Monie et al., HIV-1 integrates into resting CD4+ T cells even at low inoculums as demonstrated with an improved assay for HIV-1 integration, Virology, vol.368, pp.60-72, 2007.