Skip to Main content Skip to Navigation
Journal articles

"Menage a Trois": the evolutionary interplay between JSRV enJSRVs and domestic sheep

Abstract : Sheep betaretroviruses represent a fascinating model to study the complex evolutionary interplay between host and pathogen in natural settings. In infected sheep, the exogenous and pathogenic Jaagsiekte sheep retrovirus (JSRV) coexists with a variety of highly related endogenous JSRVs, referred to as enJSRVs. During evolution, some of them were co-opted by the host as they fulfilled important biological functions, including placental development and protection against related exogenous retroviruses. In particular, two enJSRV loci, enJS56A1 and enJSRV-20, were positively selected during sheep domestication due to their ability to interfere with the replication of related competent retroviruses. Interestingly, viruses escaping these transdominant enJSRVs have recently emerged, probably less than 200 years ago. Overall, these findings suggest that in sheep the process of endogenization is still ongoing and, therefore, the evolutionary interplay between endogenous and exogenous sheep betaretroviruses and their host has not yet reached an equilibrium.
Document type :
Journal articles
Complete list of metadata

Cited literature [94 references]  Display  Hide  Download
Contributor : Marie-Gabrielle Chautard Connect in order to contact the contributor
Submitted on : Wednesday, May 27, 2020 - 5:21:08 PM
Last modification on : Wednesday, November 17, 2021 - 12:31:33 PM


Publisher files allowed on an open archive




A. Armezzani, M. Varela, T. E. Spencer, M. Palmarini, Frederick Arnaud. "Menage a Trois": the evolutionary interplay between JSRV enJSRVs and domestic sheep. Viruses, MDPI, 2014, 6 (12), pp.4926-45. ⟨10.3390/v6124926⟩. ⟨hal-02192901⟩



Les métriques sont temporairement indisponibles