 |
Journal articles
In between: gypsy in Drosophila melanogaster reveals new insights into endogenous retrovirus evolution
Abstract : Retroviruses are RNA viruses that are able to synthesize a DNA copy of their genome and insert it into a chromosome of the host cell. Sequencing of different eukaryote genomes has revealed the presence of many such endogenous retroviral sequences. The mechanisms by which these retroviral sequences have colonized the genome are still unknown, and the endogenous retrovirus gypsy of Drosophila melanogaster is a powerful experimental model for deciphering this process in vivo. Gypsy is expressed in a layer of somatic cells, and then transferred into the oocyte by an unknown mechanism. This critical step is the start of the endogenization process. Moreover gypsy has been shown to have infectious properties, probably due to its envelope gene acquired from a baculovirus. Recently we have also shown that gypsy maternal transmission is reduced in the presence of the endosymbiotic bacterium Wolbachia. These studies demonstrate that gypsy is a unique and powerful model for understanding the endogenization of retroviruses.
Cited literature [43 references]
https://hal-univ-lyon1.archives-ouvertes.fr/hal-02192900
Contributor : Marie-Gabrielle Chautard Connect in order to contact the contributor
Submitted on : Wednesday, May 27, 2020 - 5:07:01 AM
Last modification on : Wednesday, November 17, 2021 - 12:31:23 PM
Contributor : Marie-Gabrielle Chautard Connect in order to contact the contributor
Submitted on : Wednesday, May 27, 2020 - 5:07:01 AM
Last modification on : Wednesday, November 17, 2021 - 12:31:23 PM
File
2014_Touret_Viruses_1.pdf
Publisher files allowed on an open archive