Heart rate: a prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate-lowering properties

Abstract : Heart rate not only predicts outcome but may also be a therapeutic target in patients with chronic heart failure. Several classes of pharmacological agents can be used to modulate heart rate, including beta-blockers, ivabradine, digoxin, amiodarone, and verapamil. Choice of agent will depend on heart rhythm, co-morbidities, and disease phenotype. Beneficial and harmful interactions may also exist. The aim of this paper is to summarize the current body of knowledge regarding the relevance of heart rate as a prognostic factor (risk marker) and particularly as a therapeutic target (risk factor) in patients with chronic heart failure, with a special focus on ivabradine, a novel agent that is currently the only available purely bradycardic agent.
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Submitted on : Friday, June 28, 2019 - 2:03:08 PM
Last modification on : Friday, October 11, 2019 - 8:23:28 PM

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D. Dobre, J. S. Borer, K. Fox, K. Swedberg, K. F. Adams, et al.. Heart rate: a prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate-lowering properties. European Journal of Heart Failure, Oxford University Press (OUP), 2013, 16 (1), pp.76-85. ⟨10.1093/eurjhf/hft129⟩. ⟨hal-02168111⟩

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