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Journal articles
Effects of 2,3-Dideoxyinosine on Toxoplasma gondii Cysts in Mice
Abstract : The activity against Toxoplasma gondii of 2,3 dideoxyinosine (ddI), an anti-human immunodeficiency virus drug, was examined in an in vitro and in vivo study. Cell cultures infected with a strain known to cause chronic infections were used to show the dose-dependent effect of this drug compared with spiramycin and sulfadiazine. When a dose of 4 g/ml was used, no infected THP-1 cells or parasites were found after 60 h of incubation. An electron-microscopic study confirmed that after 12 h at 1 g/ml, the few parasites observed were severely altered. The treatment of chronically infected mice 3 months postinfection showed that a 30-day treatment with 2 mg of ddI/ml induced a significant reduction in the number of T. gondii cysts in the cerebral tissue. These cysts were not viable, as confirmed by immunofluorescence and reinfection experiments. These experiments suggest a possible role for ddI in the treatment of toxoplasmosis, and this possibility deserves further investigation.
https://hal-univ-lyon1.archives-ouvertes.fr/hal-02110926
Contributor : Philippe Lawton Connect in order to contact the contributor
Submitted on : Friday, April 26, 2019 - 4:16:40 PM
Last modification on : Thursday, November 21, 2019 - 2:10:23 AM
Contributor : Philippe Lawton Connect in order to contact the contributor
Submitted on : Friday, April 26, 2019 - 4:16:40 PM
Last modification on : Thursday, November 21, 2019 - 2:10:23 AM
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