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In vitro cultivation of Cryptosporidium parvum in the non-adherent human monocytic THP-1 cell line

Philippe Lawton 1 Muriel Naciri 2 Roselyne Mancassola 2 Anne-Francoise Pétavy 1
1 Laboratoire de Parasitologie
2 PAP - Station de Pathologie aviaire et parasitologie [Nouzilly]
Abstract : This study shows that the human monocytic cell line THP-1 supports the growth of C. parvum. Immunofluorescence controls showed that only scarce oocysts remained after infection and disappeared Within the first 24 h of culture. A continuous asexual life cycle proceeded throughout the experiments, with at least 15d cultures. This model provides a useful tool for studies on the biology of C. parvum in cells involved in its transport in immunocompromised host
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Philippe Lawton, Muriel Naciri, Roselyne Mancassola, Anne-Francoise Pétavy. In vitro cultivation of Cryptosporidium parvum in the non-adherent human monocytic THP-1 cell line. Journal of Eukaryotic Microbiology, Wiley, 1997, 44 (s6), pp.66S. ⟨10.1111/j.1550-7408.1997.tb05783.x⟩. ⟨hal-02110909⟩

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