Skip to Main content Skip to Navigation
Journal articles

Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

Ting Shi 1 David Mcallister 2 Katherine O'Brien 3 Eric Simoes 4 Shabir Madhi 5 Bradford Gessner 6 Fernando Polack Evelyn Balsells Sozinho Acacio Claudia Aguayo Issifou Alassani 7 Asad Ali 8 Martin Antonio 9 Shally Awasthi 10 Juliet Awori 11 Eduardo Azziz-Baumgartner 12 Henry Baggett 13 Vicky Baillie 5 Angel Balmaseda 14 Alfredo Barahona Sudha Basnet 15 Quique Bassat 16 Wilma Basualdo Godfrey Bigogo 11 Louis Bont 17 Robert Breiman 18 W Abdullah Brooks 3 Shobha Broor 19 Nigel Bruce 20 Dana Bruden Philippe Buchy 4 Stuart Campbell Phyllis Carosone-Link 4 Mandeep Chadha James Chipeta Monidarin Chou 21 Wilfrido Clara 22 Cheryl Cohen 5 Elizabeth de Cuellar Duc-Anh Dang 23 Budragchaagiin Dash-Yandag Maria Deloria-Knoll Mukesh Dherani 20 Tekchheng Eap 24 Bernard Ebruke 9 Marcela Echavarria Carla Cecília de Freitas Lázaro Emediato Rodrigo Fasce 25 Daniel Feikin 22 Luzhao Feng 22 Angel Gentile 26 Aubree Gordon 27 Doli Goswami 12 Sophie Goyet 4 Michelle Groome Natasha Halasa 28 Siddhivinayak Hirve 29 Nusrat Homaira 12 Stephen Howie 30 Jorge Jara 31 Imane Jroundi 16 Cissy Kartasasmita Najwa Khuri-Bulos 32 Karen Kotloff Anand Krishnan 19 Romina Libster Olga Lopez Marilla Lucero 33 Florencia Lucion 26 Socorro Lupisan 33 Debora Marcone John Mccracken 31 Mario Mejia Jennifer Moisi 6 Joel Montgomery 22 David Moore Cinta Moraleda 16 Jocelyn Moyes 5 Patrick Munywoki 11 Kuswandewi Mutyara Mark Nicol 34 James Nokes 11 Pagbajabyn Nymadawa Maria da Costa Oliveira Histoshi Oshitani 35 Nitin Pandey 10 Gláucia Paranhos-Baccalà 36 Lia Phillips 37 Valentina Sanchez Picot Mustafizur Rahman 12 Mala Rakoto-Andrianarivelo 38 Zeba Rasmussen 39 Barbara Rath Annick Robinson Candice Romero Graciela Russomando 40 Vahid Salimi 41 Pongpun Sawatwong 13 Nienke Scheltema 17 Brunhilde Schweiger 42 J Anthony G Scott Phil Seidenberg 43 Kunling Shen Rosalyn Singleton 22 Viviana Sotomayor Tor Strand Agustinus Sutanto Maria Sylla Milagritos Tapia Somsak Thamthitiwat 13 Elizabeth Thomas 39 Rafal Tokarz 44 Claudia Turner Marietjie Venter 45 Sunthareeya Waicharoen 13 Jianwei Wang 46 Wanitda Watthanaworawit Lay-Myint Yoshida 47 Hongjie Yu 22 Heather Zar 34 Harry Campbell 1 Harish Nair 1
36 LPE-Fondation Mérieux - Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory
CIRI - Centre International de Recherche en Infectiologie - UMR
Abstract : BACKGROUND: We have previously estimated that respiratory syncytial virus (RSV) was associated with 22% of all episodes of (severe) acute lower respiratory infection (ALRI) resulting in 55 000 to 199 000 deaths in children younger than 5 years in 2005. In the past 5 years, major research activity on RSV has yielded substantial new data from developing countries. With a considerably expanded dataset from a large international collaboration, we aimed to estimate the global incidence, hospital admission rate, and mortality from RSV-ALRI episodes in young children in 2015. METHODS: We estimated the incidence and hospital admission rate of RSV-associated ALRI (RSV-ALRI) in children younger than 5 years stratified by age and World Bank income regions from a systematic review of studies published between Jan 1, 1995, and Dec 31, 2016, and unpublished data from 76 high quality population-based studies. We estimated the RSV-ALRI incidence for 132 developing countries using a risk factor-based model and 2015 population estimates. We estimated the in-hospital RSV-ALRI mortality by combining in-hospital case fatality ratios with hospital admission estimates from hospital-based (published and unpublished) studies. We also estimated overall RSV-ALRI mortality by identifying studies reporting monthly data for ALRI mortality in the community and RSV activity. FINDINGS: We estimated that globally in 2015, 33·1 million (uncertainty range [UR] 21·6-50·3) episodes of RSV-ALRI, resulted in about 3·2 million (2·7-3·8) hospital admissions, and 59 600 (48 000-74 500) in-hospital deaths in children younger than 5 years. In children younger than 6 months, 1·4 million (UR 1·2-1·7) hospital admissions, and 27 300 (UR 20 700-36 200) in-hospital deaths were due to RSV-ALRI. We also estimated that the overall RSV-ALRI mortality could be as high as 118 200 (UR 94 600-149 400). Incidence and mortality varied substantially from year to year in any given population. INTERPRETATION: Globally, RSV is a common cause of childhood ALRI and a major cause of hospital admissions in young children, resulting in a substantial burden on health-care services. About 45% of hospital admissions and in-hospital deaths due to RSV-ALRI occur in children younger than 6 months. An effective maternal RSV vaccine or monoclonal antibody could have a substantial effect on disease burden in this age group. FUNDING: The Bill & Melinda Gates Foundation.
Complete list of metadatas

https://hal-univ-lyon1.archives-ouvertes.fr/hal-01976733
Contributor : Christelle Cheval <>
Submitted on : Thursday, January 10, 2019 - 11:35:51 AM
Last modification on : Wednesday, June 17, 2020 - 11:36:02 AM

Links full text

Identifiers

Collections

Citation

Ting Shi, David Mcallister, Katherine O'Brien, Eric Simoes, Shabir Madhi, et al.. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study. The Lancet, Elsevier, 2017, 390 (10098), pp.946-958. ⟨10.1016/S0140-6736(17)30938-8⟩. ⟨hal-01976733⟩

Share

Metrics

Record views

110