A Method to Identify Best Available Technologies (BAT) for Hydrogenation Reactors in the Pharmaceutical Industry

Abstract : A methodology that may be applied to help in the choice of a continuous reactor is proposed. In this methodology, the chemistry is first described through the use of eight simple criteria (rate, thermicity, deactivation, solubility, conversion, selectivity, viscosity, and catalyst). Then, each reactor type is also analyzed from their capability to answer each of these criteria. A final score is presented using "spider diagrams." Lower surfaces indicate the best reactor choice. The methodology is exemplified with a model substrate nitrobenzene and a target pharmaceutical intermediate, N-methyl-4-nitrobenzenemethanesulphonamide, and for three different continuous reactors, i.e., stirred tank, fixed bed, and an advanced microstructured reactor. Comparison with the traditional batch reactor is also provided.
Complete list of metadatas

https://hal-univ-lyon1.archives-ouvertes.fr/hal-01925285
Contributor : Lauriane Pillet <>
Submitted on : Friday, November 16, 2018 - 3:34:14 PM
Last modification on : Thursday, December 13, 2018 - 3:44:06 PM

Links full text

Identifiers

Collections

Citation

Tuong van Le Doan, Petr Stavárek, Claude de Bellefon. A Method to Identify Best Available Technologies (BAT) for Hydrogenation Reactors in the Pharmaceutical Industry. Journal of flow chemistry, Akademiai Kiado, 2012, 2 (3), pp.77 - 82. ⟨10.1556/JFC-D-12-00014⟩. ⟨hal-01925285⟩

Share

Metrics

Record views

27