Further insight in the minor/major concept using hydrogen pressure effect in asymmetric hydrogenation

A. Aloui; F. Delbecq; P. Sautet; C. de Bellefon

Further insight in the minor/major concept using hydrogen pressure effect in asymmetric hydrogenation

A. Aloui ^{1, 2} F. Delbecq ² P. Sautet ² C. de Bellefon ¹

1 LGPC - Laboratoire de Génie des Procédés Catalytiques

Abstract : The catalytic system prepared from [Rh(COD)(2)]BF4 and (R,R)-Me-BPE provides a spectacular detrimental hydrogen pressure effect on ee from 94% down to 56% in the hydrogenation of methylacrylate, whereas it has a strong beneficial effect on the hydrogenation of E-emap (from 42% up to 72%). The kinetic parameters have been determined for both systems and have helped to identify the most enantioselective controlling steps (MECS). Accordingly, further explanations for the structure-ee and hydrogen pressure relationship are proposed. (c) 2012 Elsevier B.V. All rights reserved.

Document type :

Journal articles

Domain :

Chemical Sciences / Catalysis

Engineering Sciences [physics] / Chemical and Process Engineering

Chemical Sciences / Chemical engineering

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https://hal-univ-lyon1.archives-ouvertes.fr/hal-01923743
Contributor : Lauriane Pillet <>
Submitted on : Thursday, November 15, 2018 - 2:02:28 PM
Last modification on : Sunday, November 18, 2018 - 8:39:59 AM

Further insight in the minor/major concept using hydrogen pressure effect in asymmetric hydrogenation

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Further insight in the minor/major concept using hydrogen pressure effect in asymmetric hydrogenation

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