Further insight in the minor/major concept using hydrogen pressure effect in asymmetric hydrogenation

Abstract : The catalytic system prepared from [Rh(COD)(2)]BF4 and (R,R)-Me-BPE provides a spectacular detrimental hydrogen pressure effect on ee from 94% down to 56% in the hydrogenation of methylacrylate, whereas it has a strong beneficial effect on the hydrogenation of E-emap (from 42% up to 72%). The kinetic parameters have been determined for both systems and have helped to identify the most enantioselective controlling steps (MECS). Accordingly, further explanations for the structure-ee and hydrogen pressure relationship are proposed. (c) 2012 Elsevier B.V. All rights reserved.
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A. Aloui, F. Delbecq, P. Sautet, C. de Bellefon. Further insight in the minor/major concept using hydrogen pressure effect in asymmetric hydrogenation. Journal of Molecular Catalysis A: Chemical, Elsevier, 2012, 363-364, pp.214 - 222. ⟨10.1016/j.molcata.2012.06.012⟩. ⟨hal-01923743⟩

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