Effects of hydroxyurea on blood rheology in sickle cell anemia: A two-years follow-up study

Nathalie Lemonne 1 Berenike Möckesch 2 Keyne Charlot 3 Yohann Garnier 4 Xavier Waltz 3 Yann Lamarre 5 Sophie Antoine-Jonville 3 Maryse Etienne-Julan 6 Marie-Dominique Hardy-Dessources 6 Marc Romana 7 Philippe Connes 8
1 Unité Transversale de la Drépanocytose
2 Université des Antilles (Pôle Guadeloupe)
3 ACTES - Adaptation, Climat Tropical, Exercice et Santé
4 BIGR - Biologie Intégrée du Globule Rouge
5 Protéines de la membrane érythrocytaire et homologues non-érythroides
6 Laboratory of Excellence GR-Ex "The red cell: from genesis to death"
7 UAG - Université des Antilles et de la Guyane
8 LIBM - Laboratoire Interuniversitaire de Biologie de la Motricité
Abstract : The aim of the present study was to test the effects of hydroxyurea (HU) therapy on clinical, hematological and hemorheological parameters in adult patients with sickle cell anemia (SCA). Hematological and hemorheological parameters were measured in 28 SCA patients before HU therapy (i.e., baseline) and at 6, 12 and 24 months of treatment. RBC deformability was determined by ektacytometry at 30 Pa. RBC aggregation properties were investigated by light-backscatter method. Blood viscosity was measured at 225 s-1 by a cone-plate viscometer. The rates of vaso-occlusive crises and acute chest syndrome were lower at 1 and 2 years of HU therapy compared to baseline. The proportion of patients with leg ulcers tended to decrease after 2 years of treatment. Hemoglobin oxygen saturation improved with HU therapy. HU therapy induced a decrease of platelet and white blood cell counts and a rise in fetal hemoglobin level and mean cell volume. While hemoglobin concentrations increased under HU, blood viscosity remained unchanged all along the study. RBC deformability increased over baseline values at 6 months of HU therapy and continued to rise until the end of the follow-up period. In conclusion, the improvement in RBC deformability probably compensates the increase of hemoglobin on blood viscosity and participates to the improvement of the clinical status of patients.
Keywords : clinical severity sickle cell disease Hydroxyurea blood rheology
Document type :
Journal articles
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https://hal-univ-lyon1.archives-ouvertes.fr/hal-01881701
Contributor : Philippe Connes <>
Submitted on : Wednesday, September 26, 2018 - 11:15:56 AM
Last modification on : Thursday, July 11, 2019 - 10:08:58 AM

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Nathalie Lemonne, Berenike Möckesch, Keyne Charlot, Yohann Garnier, Xavier Waltz, et al.. Effects of hydroxyurea on blood rheology in sickle cell anemia: A two-years follow-up study. Clinical Hemorheology and Microcirculation, IOS Press, 2017, 67 (2), pp.141 - 148. ⟨10.3233/CH-170280⟩. ⟨hal-01881701⟩

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