Impaired oxygen uptake efficiency slope and off-transient kinetics of pulmonary oxygen uptake in sickle cell anemia are associated with hemorheological abnormalities

Keyne Charlot 1 Xavier Waltz 1 Mona Hedreville 1 Stéphane Sinnapah 1 Nathalie Lemonne 2 Maryse Etienne-Julan 3 Valérie Soter 4 Olivier Hue 1 Marie-Dominique Hardy-Dessources 5 Philippe Connes 1, 6
1 ACTES - Adaptation, Climat Tropical, Exercice et Santé
2 Unité Transversale de la Drépanocytose
3 Protéines de la membrane érythrocytaire et homologues non-érythroides
4 CHU Pointe-à-Pitre/Abymes [Guadeloupe]
5 Université des Antilles (Pôle Guadeloupe)
6 LIBM - Laboratoire Interuniversitaire de Biologie de la Motricité
Abstract : Oxygen uptake efficiency slope (OUES) and excess post-exercise oxygen consumption (EPOC) are markers of physical fitness in the general population but have never been characterized in sickle cell anemia (SCA) where hematological and hemorheological properties are severely altered. Eight SCA patients and eleven healthy subjects (CONT) performed a submaximal incremental exercise conducted until the first ventilatory threshold (VT1). OUES was calculated from the data collected during the incremental period and EPOC parameters (amplitude [A] and time constant [τ]) were calculated from the data measured during exercise recovery. We found that OUES (p = 0.007) and A (p = 0.010) were lower, and τ (p = 0.035) was higher, in SCA patients compared to CONT subjects. OUES and τ were significantly correlated with hematocrit, red blood cell (RBC) deformability and RBC aggregates strength. Our findings suggest that both the abilities to use oxygen during exercise and to recover after a physical activity are impaired in SCA patients. This poor physical fitness seems to depend on the degree of anemia and RBC rheological alterations.
Keywords : Physical activity exercise recovery hemorheology physical fitness sickle cell disease
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Journal articles
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https://hal-univ-lyon1.archives-ouvertes.fr/hal-01881498
Contributor : Philippe Connes <>
Submitted on : Wednesday, September 26, 2018 - 8:55:35 AM
Last modification on : Thursday, July 11, 2019 - 10:08:58 AM

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Keyne Charlot, Xavier Waltz, Mona Hedreville, Stéphane Sinnapah, Nathalie Lemonne, et al.. Impaired oxygen uptake efficiency slope and off-transient kinetics of pulmonary oxygen uptake in sickle cell anemia are associated with hemorheological abnormalities. Clinical Hemorheology and Microcirculation, IOS Press, 2015, 60 (4), pp.413 - 421. ⟨10.3233/CH-141891⟩. ⟨hal-01881498⟩

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