The paradox of the serrated sickle erythrocyte: The importance of the red blood cell membrane topography

Samir Ballas Philippe Connes 1, 2
1 ACTES - Adaptation, Climat Tropical, Exercice et Santé
2 LIBM - Laboratoire Interuniversitaire de Biologie de la Motricité
Abstract : Red blood cell rheology and adhesiveness play a key role in the occurrence of vaso-occlusive like events in sickle cell anemia. The present paper reviews counter-intuitive findings supporting that rigid and serrated sickle red blood cells do not initiate vaso-occlusion. Instead, the less rigid red blood cells could initiate vaso-occlusion because of their increased adhesiveness to the vascular wall. We suspect that stiffness of sickle erythrocytes and the topography of RBC membrane are factors affecting adhesion to the endothelium.
Keywords : Sickle serrated sickle topography
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Journal articles
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Contributor : Philippe Connes <>
Submitted on : Wednesday, September 26, 2018 - 8:50:52 AM
Last modification on : Thursday, July 11, 2019 - 10:08:58 AM

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UNIV-LYON1 | UNIV-AG | UNIV-ST-ETIENNE | UNIV-SAVOIE | UGA

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Samir Ballas, Philippe Connes. The paradox of the serrated sickle erythrocyte: The importance of the red blood cell membrane topography. Clinical Hemorheology and Microcirculation, IOS Press, 2016, 63 (2), pp.149 - 152. ⟨10.3233/CH-152014⟩. ⟨hal-01881493⟩

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