The paradox of the serrated sickle erythrocyte: The importance of the red blood cell membrane topography

Abstract : Red blood cell rheology and adhesiveness play a key role in the occurrence of vaso-occlusive like events in sickle cell anemia. The present paper reviews counter-intuitive findings supporting that rigid and serrated sickle red blood cells do not initiate vaso-occlusion. Instead, the less rigid red blood cells could initiate vaso-occlusion because of their increased adhesiveness to the vascular wall. We suspect that stiffness of sickle erythrocytes and the topography of RBC membrane are factors affecting adhesion to the endothelium.
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Submitted on : Wednesday, September 26, 2018 - 8:50:52 AM
Last modification on : Thursday, July 11, 2019 - 10:08:58 AM

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Samir Ballas, Philippe Connes. The paradox of the serrated sickle erythrocyte: The importance of the red blood cell membrane topography. Clinical Hemorheology and Microcirculation, IOS Press, 2016, 63 (2), pp.149 - 152. ⟨10.3233/CH-152014⟩. ⟨hal-01881493⟩

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