HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Correlates of LDL-cholesterol goal attainment in patients under lipid lowering therapy

Abstract : BACKGROUND: LDL-cholesterol therapeutic objectives attainment under lipid lowering therapy remains inadequate. The correlates of LDL-cholesterol therapeutic objective attainment have not been thoroughly explored in an observational setting. METHODS: Patients under lipid lowering therapy and managed by general practitioners were included. LDL-cholesterol therapeutic objective was defined according to the number of cardiovascular risk factors associated with dyslipidemia (AFSSAPS-2005 guidelines). RESULTS: Most of the 2727 patients (mean age: 64.7+/-11.0) received a statin (70.0%) or a fibrate (24.3%) in monotherapy. 58.5% of patients at high cardiovascular risk did not reach therapeutic objective. Compared to simvastatin, patients receiving fibrates were less likely to be at therapeutic objective (OR=0.38, 95% CI=[0.26-0.54]). So were patients receiving fluvastatin (OR=0.41, IC95%=[0.26-0.64]) or pravastatin (OR=0.49, IC95%=[0.35-0.70]) at the dosages used by GPs. No significant difference appeared with atorvastatin (OR=0.99, 95% CI=[0.71-1.39]) or rosuvastatin (OR=1.25, CI95%=[0.77-2.02]). Patients with LDL-cholesterol levels\\textless0.7 g/L tended to be prescribed high doses of lipid lowering therapy. CONCLUSIONS: In real conditions of lipid lowering therapy use, LDL-cholesterol therapeutic objective attainment was inadequate in high-risk patients, and TO differences were observed between drugs at prescribed doses.
Document type :
Journal articles
Complete list of metadata

Contributor : Christelle Cheval Connect in order to contact the contributor
Submitted on : Friday, July 13, 2018 - 4:45:59 PM
Last modification on : Friday, January 21, 2022 - 3:28:42 AM

Links full text



L. Laforest, Philippe Moulin, Thierry Souchet, Cécile Ritleng, Gaëlle Desamericq, et al.. Correlates of LDL-cholesterol goal attainment in patients under lipid lowering therapy. Atherosclerosis, 2008, 199 (2), pp.368--377. ⟨10.1016/j.atherosclerosis.2007.11.033⟩. ⟨hal-01838993⟩



Record views