Correlates of adherence to respiratory drugs in COPD patients

L. Laforest 1 Francois Denis 2 Eric van Ganse Cecile Ritleng Christel Saussier Nadine Passante Gilles Devouassoux 3 Gerard Chatté Nathalie Freymond 4 Yves Pacheco 5
1 HESPER - Health Service and Performance Research
2 LIF - Laboratoire d'informatique Fondamentale de Marseille - UMR 6166
3 Service de Pneumologie
4 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
5 Immunovirologie et polymorphisme génétique
Abstract : AIMS: To identify the correlates of accidental omissions and intentional interruptions of respiratory therapy in COPD. METHODS: COPD patients (GOLD stages II-IV) were recruited by general practitioners or respiratory physicians. Patients reported in self-report questionnaires their adherence to respiratory drugs (over the past three months) and their perception of therapy. RESULTS: 179 patients were included (mean age 63 years, 24% females). 45% forgot their respiratory therapy, while 30% interrupted it in the absence of any perceived benefit. The risks of accidental omissions were significantly higher when patients complained about having too many medications to take on a daily basis (OR=2.35; 95%CI=1.13-4.89), and among current smokers (OR=2.14; 95%CI=1.07-4.29). Females were more likely to interrupt therapy intentionally (OR=2.40; 95%CI=1.04-5.53). Surprisingly, there was no significant relationship with the number of drugs actually taken by patients. CONCLUSIONS: Adherence to respiratory drugs is inadequate in COPD patients. In order to improve adherence, patients' perception of the burden of therapy should not be overlooked.
Keywords : Female Humans Male Aged Middle Aged Adult Multivariate Analysis Logistic Models Age Factors Severity of Illness Index Sex Factors Cross-Sectional Studies Smoking Chronic Obstructive Medication Adherence Pulmonary Disease Respiratory System Agents
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Journal articles
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https://hal-univ-lyon1.archives-ouvertes.fr/hal-01838988
Contributor : Christelle Cheval <>
Submitted on : Friday, July 13, 2018 - 4:45:52 PM
Last modification on : Thursday, November 21, 2019 - 2:22:57 AM

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L. Laforest, Francois Denis, Eric van Ganse, Cecile Ritleng, Christel Saussier, et al.. Correlates of adherence to respiratory drugs in COPD patients. Primary Care Respiratory Journal: Journal of the General Practice Airways Group, 2010, 19 (2), pp.148--154. ⟨10.4104/pcrj.2010.00004⟩. ⟨hal-01838988⟩

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