Impact of vitamin D supplementation on health-care use in a 25-hydroxyvitamin D-tested population in France: a population-based descriptive cohort study

Pascal Caillet 1 Susan B Jaglal L. Laforest 2 Roland Chapurlat 3 Muriel Rabilloud 4, 5 Michel Ducher 1 Anne-Marie Schott 1
1 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
2 HESPER - Health Service and Performance Research
3 LYOS - Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases
4 Département de Biostatistiques
5 Biostatistiques santé
Département biostatistiques et modélisation pour la santé et l'environnement [LBBE]
Abstract : OBJECTIVE: Chronic vitamin D deficiency has been associated in some patients with diffuse musculoskeletal pain. These unspecific symptoms may partly explain why vitamin D deficiency is often diagnosed late. Our aim was to analyse health-care claims after vitamin D supplementation in patients likely to have vitamin D deficiency. DESIGN: Ambulatory health-care claims were compared before and after a vitamin D supplementation prescribed following a 25-hydroxyvitamin D assay. SETTING: Health Insurance Fund (FHIF) database of the Rhône-Alpes area, France. SUBJECTS: Among patients reimbursed for a 25-hydroxyvitamin D assay between 1 December 2008 and 31 January 2009, those supplemented with vitamin D after the assay were matched on the date of assay to patients who did not receive vitamin D. RESULTS: Among the 3023 patients who had a 25-hydroxyvitamin D assay, 935 were consequently supplemented and matched to 935 patients not supplemented. Their median age was 50\textperiodcentered0 and 49\textperiodcentered5 years, respectively. Patients supplemented decreased their muscle relaxant consumption whereas no change was observed in the reference group, the difference between the two groups was significant (P=0\textperiodcentered03). Second and third Pain Relief Ladder prescriptions decreased in both groups but not significantly differently between groups (P=0\textperiodcentered58). There was a decrease in prescriptions of biological examination in both groups with no significant difference. CONCLUSIONS: Besides a decrease in muscle relaxant prescriptions in the supplemented group, it was difficult to assess the impact of vitamin D supplementation in patients likely to have vitamin D deficiency. Prospective cohort studies and randomized trials are needed to assess the efficiency of screening and supplementing vitamin D deficiency.
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Journal articles
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Submitted on : Friday, July 13, 2018 - 4:45:44 PM
Last modification on : Tuesday, July 9, 2019 - 2:20:03 PM

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Pascal Caillet, Susan B Jaglal, L. Laforest, Roland Chapurlat, Muriel Rabilloud, et al.. Impact of vitamin D supplementation on health-care use in a 25-hydroxyvitamin D-tested population in France: a population-based descriptive cohort study. Public Health Nutrition, Cambridge University Press (CUP), 2014, pp.1--11. ⟨10.1017/S136898001400038X⟩. ⟨hal-01838983⟩

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