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Recurrent Wheezing in Infants: A Population-Based Study

Abstract : Recurrent wheezing (RW) has a significant impact on infants, caregivers, and society, but morbidity and related medical resource utilization (MRU) have not been thoroughly explored. The burden of RW needs to be documented with population-based data. The objective was to assess the characteristics, medical management, and MRU of RW infants identified from national claims data.Infants aged from 6 to 24 months, receiving >=2 dispensations of respiratory drugs within 3 months, and presenting a marker of poor control (index date), were selected. During the 6 months after index date, MRU was described in the cohort and among 3 subgroups with more severe RW, defined as >=4 dispensations of respiratory drugs, >=3 dispensations of oral corticosteroids (OCS), or >=1 hospitalization for respiratory symptoms.A total of 115,489 infants had RW, corresponding to 8.2% of subjects in this age group. During follow-up, 68.7% of infants received inhaled corticosteroids, but only 1.8 U (unit) were dispensed over 6 months, suggesting discontinuous use. Control was mostly inadequate: 61.7% of subjects received OCS, 80.2% antibiotics, and 71.2% short-acting beta-agonists, and medical/paramedical visits were numerous, particularly for physiotherapy. Severe RW concerned 39.0% of the cohort; 32.8% and 11.7% of infants had repeated use of respiratory drugs and OCS, respectively, and 5.5% were hospitalized for respiratory symptoms.In this real-life nation-wide study, RW was common and infants had poor control and high MRU. Interventions are needed to support adequate use of controller therapy, and to improve medical care.
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Submitted on : Friday, July 13, 2018 - 4:45:13 PM
Last modification on : Saturday, September 24, 2022 - 2:36:04 PM

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Manon Belhassen, Jacques de Blic, L. Laforest, Valérie Laigle, Céline Chanut-Vogel, et al.. Recurrent Wheezing in Infants: A Population-Based Study. Medicine, Lippincott, Williams & Wilkins, 2016, 95 (15), pp.e3404. ⟨10.1097/MD.0000000000003404⟩. ⟨hal-01838969⟩



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