Treatment patterns and comparative effectiveness in elderly acute myeloid leukemia patients (age 70 years or older): the Lyon-university hospital experience

Abstract : The treatment of very elderly patients (\textgreater/=70 years) with acute myeloid leukemia remains controversial. We present here 302 patients seen over a 14-year period in order to understand the real-world treatment patterns and outcomes in this patient population. Less than 25% of patients achieved a complete remission. The median overall survival was 12.4, 11.5 and 2.6 months, with a 3-year rates of 27%, 17% and 6%, for non-acute promyelocytic leukemia patients receiving intensive chemotherapy, lower-intensity therapy or best supportive care (BSC), respectively. In all ages, results were not significantly different among patients receiving low-intensity therapy and intensive chemotherapy, but significantly worse in those treated with BSC only. Similarly, intensive chemotherapy and low-intensity therapy gave better survival rates than BSC in patients with favorable- or intermediate-risk cytogenetics and in those with unfavorable cytogenetics (p \textless 0.0001 and p = 0.04, respectively)
Document type :
Journal articles
Complete list of metadatas

https://hal-univ-lyon1.archives-ouvertes.fr/hal-01795720
Contributor : Lauriane Pillet <>
Submitted on : Friday, May 18, 2018 - 4:39:06 PM
Last modification on : Thursday, July 18, 2019 - 2:44:03 PM

Identifiers

Collections

Citation

M. Heiblig, Jeune C. Le, M. Elhamri, M. Balsat, I. Tigaud, et al.. Treatment patterns and comparative effectiveness in elderly acute myeloid leukemia patients (age 70 years or older): the Lyon-university hospital experience. Leukemia & lymphoma, Taylor & Francis, 2017, 58, pp.110-117. ⟨10.1080/10428194.2016.1180688⟩. ⟨hal-01795720⟩

Share

Metrics

Record views

55