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Article Dans Une Revue Scientific Reports Année : 2022

Nigratine as dual inhibitor of necroptosis and ferroptosis regulated cell death

Morgane Rousselot
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Résumé

Nigratine (also known as 6E11), a flavanone derivative of a plant natural product, was characterized as highly specific non-ATP competitive inhibitor of RIPK1 kinase, one of the key components of necroptotic cell death signaling. We show here that nigratine inhibited both necroptosis (induced by Tumor Necrosis Factor-α) and ferroptosis (induced by the small molecules glutamate, erastin, RSL3 or cumene hydroperoxide) with EC 50 in the µM range. Taken together, our data showed that nigratine is a dual inhibitor of necroptosis and ferroptosis cell death pathways. These findings open potential new therapeutic avenues for treating complex necrosis-related diseases.

Domaines

Pharmacologie
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Dates et versions

hal-03624406 , version 1 (30-03-2022)

Identifiants

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Claire Delehouzé, Arnaud Comte, Stephen Leon-Icaza, Céline Cougoule, Marcelle Hauteville, et al.. Nigratine as dual inhibitor of necroptosis and ferroptosis regulated cell death. Scientific Reports, 2022, 12, pp.5118. ⟨10.1038/s41598-022-09019-w⟩. ⟨hal-03624406⟩
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