11 C-Labeling: Intracyclic Incorporation of Carbon-11 into Heterocycles

François Liger (1) , Florence Cadarossanesaib (2) , Thibaut Iecker , Christian Tourvieille , Didier Le Bars (3) , Thierry Billard (4)

1 ICBMS - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires
2 CERMEP - imagerie du vivant - Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant
3 UCBL - Université Claude Bernard Lyon 1
4 SURCOOF - Synthèse, Utilisation, Réactivité des Composés Organiques et OrganoFluorés

Labeling of heterocycles with carbon-11 is generally performed through peripheral functionalizations and more scarcely inside heterocyclic core. Such less common approach usually requires preliminary multi-step synthesis of reactive species. Herein, a cyclization reaction by direct use of cyclotron-produced [ 11 C]CO2 is described to obtain various heterocycles intracyclically labeled in only 10 minutes.

Domaines: Chimie; Radiochimie

François Liger, Florence Cadarossanesaib, Thibaut Iecker, Christian Tourvieille, Didier Le Bars, et al.. 11 C-Labeling: Intracyclic Incorporation of Carbon-11 into Heterocycles. European Journal of Organic Chemistry, 2019, 2019 (41), pp.6968-6972. ⟨10.1002/ejoc.201901386⟩. ⟨hal-02382036⟩